RH12
RH12 is a dual inhibitor for SARS-CoV-2 related RNA-dependent RNA polymerase (RdRp, IC50 is 4.42 nM) and human transmembrane serine protease 2 (TMPRSS2, IC50 is 4.2 nM). RH12 exhibits antiviral efficacy. RH12 inhibits viral replication and absorption, and exhibits a 90.5% virucidal effects on Vero-E6 cells. RH12 inhibits cell viability of Calu-3 with an IC50 of 17.5 nM.
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- Fòrmula: C20H19N3O4
- Peso molecular:365.38
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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RNA Polymerase |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Calu-3 | CC50 |
450 nM
Compound: RH12
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Cytotoxicity against human Calu-3 cells
Cytotoxicity against human Calu-3 cells
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[PMID: 39004019] |
| Vero C1008 | CC50 |
130.3 nM
Compound: RH12
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Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability incubated for 72 hrs by crystal violet staining based analysis
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability incubated for 72 hrs by crystal violet staining based analysis
|
[PMID: 39004019] |
Chemical Information
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Peso molecular 365.38
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Fòrmula C20H19N3O4
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SMILES
N=C(N)NC1=CC=C(C(OC2=CC=C(OC(C=C3C(C)C)=O)C3=C2)=O)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)