Seletracetam
Based on 1 publication(s) in Google Scholar
Seletracetam (Ucb 44212), as an analog of the antiepileptic agent Levetiracetam, is a SV2A modulator for the research of epilepsy.
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- Pureza : 99.70%
- No. CAS: 357336-74-4
- Fòrmula: C10H14F2N2O2
- Peso molecular:232.23
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Almacenamiento:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Seletracetam
More
Actividad biológica
Descripciòn
IC50 & Target
SV2A[1]
In Vitro
Seletracetam decreases seizure activity in a number of epilepsy models and binds to the synaptic vesicle protein SV2A[2].
Seletracetam decreases synaptic responses in a time-, frequency- and concentration-dependent manner[2].
Seletracetam modifies rates of presynaptic release[2].
Seletracetam inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 357336-74-4
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Appearance Solid
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Peso molecular 232.23
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Fòrmula C10H14F2N2O2
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Color Off-white to light yellow
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SMILES
O=C([C@@H](N1C(C[C@H](C1)/C=C(F)\F)=O)CC)N
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Synonyms
Ucb 44212
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Ann Neurol
Intranasal Seletracetam in a Patient with Reading Epilepsy: First-in-Human Use to Prevent Reflex Seizures. [Abstract]2025 Dec 29. PMID: 41459805
Solvente y solubilidad
In Vitro:
DMSO : 200 mg/mL (861.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Pollard JR, et al. Seletracetam, a small molecule SV2A modulator for the treatment of epilepsy. Curr Opin Investig Drugs. 2008 Jan;9(1):101-7. [Content Brief]
[2]. Martella G, et al. Seletracetam (ucb 44212) inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro. Epilepsia. 2009 Apr;50(4):702-10. [Content Brief]
[3]. Yang X, et al. Seletracetam enhances short term depression in vitro. Epilepsy Res. 2015 Nov;117:17-22. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.3061 mL | 21.5304 mL | 43.0608 mL | 107.6519 mL |
| 5 mM | 0.8612 mL | 4.3061 mL | 8.6122 mL | 21.5304 mL | |
| 10 mM | 0.4306 mL | 2.1530 mL | 4.3061 mL | 10.7652 mL | |
| 15 mM | 0.2871 mL | 1.4354 mL | 2.8707 mL | 7.1768 mL | |
| 20 mM | 0.2153 mL | 1.0765 mL | 2.1530 mL | 5.3826 mL | |
| 25 mM | 0.1722 mL | 0.8612 mL | 1.7224 mL | 4.3061 mL | |
| 30 mM | 0.1435 mL | 0.7177 mL | 1.4354 mL | 3.5884 mL | |
| 40 mM | 0.1077 mL | 0.5383 mL | 1.0765 mL | 2.6913 mL | |
| 50 mM | 0.0861 mL | 0.4306 mL | 0.8612 mL | 2.1530 mL | |
| 60 mM | 0.0718 mL | 0.3588 mL | 0.7177 mL | 1.7942 mL | |
| 80 mM | 0.0538 mL | 0.2691 mL | 0.5383 mL | 1.3456 mL | |
| 100 mM | 0.0431 mL | 0.2153 mL | 0.4306 mL | 1.0765 mL |
Seletracetam Related Classifications
HY-119810 Related Classifications
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