SHP244
SHP244 is a conformational inhibitor targeting the "latch allosteric site" (site 2) of the SHP2 protein with an IC50 value for SHP2WT of 60 μM. SHP244 has no significant effect on the level of p-ERK alone. SHP244 combined with RMC-4550 (HY-116009) ("tunnel site" site 1 inhibitor) can reduce p-ERK and inhibit the rebound of p-ERK, thereby reducing drug resistance. SHP244 can be used to study drug resistance in FGFR-driven cancers.
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- No. CAS: 902891-37-6
- Fòrmula: C23H17ClN4O3
- Peso molecular:432.86
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Chemical Information
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No. CAS 902891-37-6
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Peso molecular 432.86
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Fòrmula C23H17ClN4O3
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SMILES
O=C1C2=C(N3C(C4=C(O)C(OC)=CC=C4)=NN=C3N1CC5=C(Cl)C=CC=C5)C=CC=C2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SHP244 Related Classifications
HY-115527 Related Classifications
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