Sozinibercept
Based on 1 Customer Validation
Sozinibercept (OPT 302; VGX-300) is a soluble form of VEGFR-3, potently inhibits the activity of VEGF-C/D, which are the proangiogenic factors, inhibiting angiogenesis and vascular leakage. Sozinibercept also inhibits diabetic retinal edema in rats.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.52%
- No. CAS: 2568358-31-4
- Peso molecular:120.85 kDa
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
Ver todos los productos específicos de isoformas VEGFR
More
Actividad biológica
Descripciòn
IC50 & Target
In Vivo
Sozinibercept (intravitreal injection; once every 4 wk for 4 months) shows selective inhibition of VEGF-C/D, and inhibits diabetic retinal edema induced by streptozotocin (STZ) in the rat model, and equivalent to inhibition of VEGF-A inhibitor (Aflibercept)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
-
[FLT4 (fms related receptor tyrosine kinase 4, vascular endothelial growth factor receptor 3, VEGFR3, PCL, VEGFR-3)fragment (1-305, containing the immunoglobulin-like C2-type domains 1, 2 and 3)]2-IGHG1 Fc (Fragment constant)
Aplicación
ELISA, FACS, Functional assay
Chemical Information
-
No. CAS 2568358-31-4
-
Appearance Liquid
-
Peso molecular 120.85 kDa
-
Color Colorless to light yellow
-
SMILES
[Sozinibercept]
-
Synonyms
OPT 302; VGX-300
-
Envío
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
-
Ficha de datos (258 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Inhibitory Antibodies User Guide (603 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)