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Referencia número: HY-114606

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SW208108

SW208108 is a prodrug of dMe-SW208108, a CYP4F11-activated SCD inhibitor, with an IC₅₀ value of 9 nM. SW208108 undergoes demethylation by CYP4F11 to form the active metabolite dMe-SW208108, thereby inhibiting enzyme function. SW208108 depletes unsaturated fatty acids, induces cytotoxicity in non-small cell lung cancer (NSCLC) cells expressing CYP4F11, and does not affect SCD activity in mouse sebocytes. SW208108 can be used in studies related to NSCLC.

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No. CAS: 1673557-43-1
Fòrmula: C₂₇H₂₄N₂O₅
Peso molecular:456.50

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

SW208108 Chemical Structure

No. CAS: 1673557-43-1

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Actividad biológica

Descripciòn

In Vitro

SW208108 selectively reduces the viability of four NSCLC cell lines (H2122, H460, HCC44, HCC4017) with an IC₅₀ of 0.014-0.031 μM; it exhibits moderate toxicity against H2073 cells, but shows no toxicity against another seven NSCLC cell lines^[1].
SW208108 is selectively metabolized to dMe-SW208108 in H2122 non-small cell lung cancer cells, whereas it remains unmetabolized in H1155 non-small cell lung cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 1673557-43-1
Peso molecular 456.50
Fòrmula C₂₇H₂₄N₂O₅
SMILES

O=C(NC1=CC=C(C=C1)C(=O)C2=CC=C(OCC#C)C=C2)C(=O)NCCC3=CC=C(OC)C=C3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Theodoropoulos PC, et al. Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase. Nature chemical biology. 2016 Apr;12(4):218-25. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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