trans-Ned 19 (Standard)
trans-Ned 19 (Standard) is the analytical standard of trans-Ned 19 (HY-103316). This product is intended for research and analytical applications. trans-Ned 19 is a NAADP antagonist and TPC blocker. trans-Ned 19 suppresses the calcium signal and the rat aorta relaxation in response to low histamine concentrations. trans-Ned 19 increases the spontaneous acrosome reaction rate, alleviates anti-CD3 mAb-induced intestinal inflammation, and improves kidney damage in mice with nephrotoxic serum nephritis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1354235-96-3
- Fòrmula: C30H31FN4O3
- Peso molecular:514.59
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Product Information
-
Chemical Information
- Pureza y Documentación
-
Help & FAQs
-
HY-103316
trans-Ned 19NAADP Antagonist -
HY-13434
IonomycinCalcium Ionophore -
HY-13434A
Ionomycin calciumCalcium Ionophore -
HY-15124
(S)-(-)-Bay-K-8644Calcium Channel Agonist -
HY-B0358A
Flunarizine dihydrochlorideNa+/Ca2+ Channel Blocker -
HY-15125
(R)-(+)-Bay-K-8644Calcium Channel Inhibitor -
HY-B0358AR
Flunarizine dihydrochloride (Standard)Na+/Ca2+ Channel Blocker -
HY-13434AR
Ionomycin calcium (Standard)Calcium Ionophore
Product Information
Information
Aplicación
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
-
No. CAS 1354235-96-3
-
Peso molecular 514.59
-
Fòrmula C30H31FN4O3
-
SMILES
O=C([C@@H]1CC2=C([C@@H](C3=CC=C(OC)C(CN4CCN(C5=CC=CC=C5F)CC4)=C3)N1)NC6=C2C=CC=C6)O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Nawrocki M, et al. Trans-Ned 19-Mediated Antagonism of Nicotinic Acid Adenine Nucleotide-Mediated Calcium Signaling Regulates Th17 Cell Plasticity in Mice. Cells. 2021 Nov 5;10(11):3039. [Content Brief]
[2]. Trufanov SK, et al. The Role of Two-Pore Channels in Norepinephrine-Induced [Ca2+]i Rise in Rat Aortic Smooth Muscle Cells and Aorta Contraction. Cells. 2019 Sep 25;8(10):1144. [Content Brief]
[5]. Arndt L, et al. NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa. Mol Biol Cell. 2014 Mar;25(6):948-64. [Content Brief]
[6]. Zharkich IL, et al. Suppression of Histamine-Induced Relaxation of Rat Aorta and Calcium Signaling in Endothelial Cells by Two-Pore Channel Blocker trans-NED19 and Hydrogen Peroxide. Izv Akad Nauk Ser Biol. 2016 Jul;(4):430-438. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
trans-Ned 19 (Standard) Related Classifications
HY-103316R Related Classifications
Powered by Bioz