UPG-111
UPG-111 is a peptide compound that acts as a negative allosteric modulator of the Urotensin II receptor (UTR). UPG-111 exhibits a dual inhibitory effect on the vasoconstriction induced by UTR agonists - it reduces both the maximum response intensity and the sensitivity of the agonist. UPG-111 does not induce calcium release or cause contraction of the endothelium-deprived rat aortic rings. UPG-111 can be used for the study of various diseases related to the angiotensinergic system.
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- No. CAS: 3090687-02-5
- Fòrmula: C64H87N13O17S2
- Peso molecular:1374.58
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Chemical Information
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No. CAS 3090687-02-5
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Peso molecular 1374.58
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Fòrmula C64H87N13O17S2
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Sequence
{hSer}-{TPED}-{Pen}-Phe-{d-Trp}-{Orn}-Tyr-Cys-Val (Disulfide bridge: Pen-Cys)
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Sequence Shortening
{hSer}-{TPED}-{Pen}-F-{d-Trp}-{Orn}-YCV (Disulfide bridge: Pen-Cys)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UPG-111 Related Classifications
HY-P11259 Related Classifications
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- UPG-111
- 3090687-02-5
- UPG111
- UPG 111
- Urotensin Receptor
- Urotensin II receptor (UTR) modulators
- Negative allosteric modulator (NAM)
- Lateral allostery
- GPCR multimeric model
- Structure-activity relationship (SAR)
- N-terminal peptide engineering
- Noncompetitive antagonism
- Calcium mobilization
- Rat aorta contraction
- Inhibitor
- inhibitor
- inhibit