ZG-2291
Based on 1 Customer Validation
ZG-2291 is a selective inhibitor targeting FIH (Factor Inhibiting HIF) with oral activity. By binding to FIH, ZG-2291 promotes a conformational flip of a catalytically important tyrosine, enabling selective inhibition of FIH without affecting other 2OG oxygenases in the JmjC subfamily. ZG-2291k enhances thermogenesis in ob/ob mice and improves obesity-related symptoms and metabolic dysfunctions. ZG-2291 holds promise for research in the field of obesity-related diseases.
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- Pureza: 98.08%
- No. CAS: 2962103-40-6
- Fòrmula: C17H12ClN3O5
- Peso molecular:373.75
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
ZG-2291 (5 and 20 μM, 48 h) is an active cell-penetrating FIH inhibitor in Hep3B cells[1]. ZG-2291 (5 and 20 μM, 48 h) promotes thermogenesis and improves lipid accumulation in 3T3-L1-derived adipocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Hep3B cells
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Concentration:5, 20 μM
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Incubation Time:48 h
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Result:Clearly upregulated the expression of the HIF target gene EGLN3, while the upregulation effect on other HIF target genes such as SLC2A1, BNIP3, and EPO was relatively mild.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ob/ob mice
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection (i.p.), every other day for a total of 30 days
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Result:Resulted in lower body weight, reduced hepatic TG/TC, and lower serum TG/TC/low-density lipoprotein (LDL) cholesterol levels in mice compared to the control group
Chemical Information
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No. CAS 2962103-40-6
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Appearance Solid
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Peso molecular 373.75
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Fòrmula C17H12ClN3O5
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Color Off-white to light yellow
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SMILES
O=C(O)CNC(C1=NC=C(C2=CC(C3=CC=CC(Cl)=C3)=NO2)C=C1O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 50 mg/mL (133.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6756 mL | 13.3779 mL | 26.7559 mL | 66.8896 mL |
| 5 mM | 0.5351 mL | 2.6756 mL | 5.3512 mL | 13.3779 mL | |
| 10 mM | 0.2676 mL | 1.3378 mL | 2.6756 mL | 6.6890 mL | |
| 15 mM | 0.1784 mL | 0.8919 mL | 1.7837 mL | 4.4593 mL | |
| 20 mM | 0.1338 mL | 0.6689 mL | 1.3378 mL | 3.3445 mL | |
| 25 mM | 0.1070 mL | 0.5351 mL | 1.0702 mL | 2.6756 mL | |
| 30 mM | 0.0892 mL | 0.4459 mL | 0.8919 mL | 2.2297 mL | |
| 40 mM | 0.0669 mL | 0.3344 mL | 0.6689 mL | 1.6722 mL | |
| 50 mM | 0.0535 mL | 0.2676 mL | 0.5351 mL | 1.3378 mL | |
| 60 mM | 0.0446 mL | 0.2230 mL | 0.4459 mL | 1.1148 mL | |
| 80 mM | 0.0334 mL | 0.1672 mL | 0.3344 mL | 0.8361 mL | |
| 100 mM | 0.0268 mL | 0.1338 mL | 0.2676 mL | 0.6689 mL |
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