CHST4 - carbohydrate sulfotransferase 4 Gene

Also Known as GST3; LSST; GlcNAc6ST2; HECGLCNAC6ST

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10164

About CHST4

This gene has 3 transcripts (splice variants), 112 orthologues and 6 paralogues. Restricted expression toward gall bladder (RPKM 42.6).

Summary

This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3'phosphoadenosine 5'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]

CHST4 Products (2)

mRNA Protein Name
NM_001166395.2 NP_001159867.1 carbohydrate sulfotransferase 4
NM_005769.2 NP_005760.1 carbohydrate sulfotransferase 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables N-acetylglucosamine 6-O-sulfotransferase activity IDA
IDA: Inferred from direct assay
10330415 GOA
Biological Process GO Annotation Evidence References Source
involved in N-acetylglucosamine metabolic process IDA
IDA: Inferred from direct assay
10330415 GOA
involved in sulfur compound metabolic process IDA
IDA: Inferred from direct assay
10330415 GOA
Cellular Component GO Annotation Evidence References Source
located in trans-Golgi network IDA
IDA: Inferred from direct assay
12855678 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHST4 Protein Structure

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (44 - 357)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
Protein Preferred Names Protein Names

carbohydrate sulfotransferase 4

  • GST-3

Related Diseases

Diseases Alias
Mucinous Adenocarcinoma

  • Mucin-Producing Adenocarcinoma

  • Mucin-Secreting Adenocarcinoma

  • Mucin-Secreting Carcinoma

  • Mucous Carcinoma

  • Pseudomyxoma Peritonei With Unknown Primary Site

  • Adenocarcinoma, Mucinous
Colon Mucinous Adenocarcinoma

  • Colonic Mucinous Adenocarcinoma

  • Mucinous Adenocarcinoma Of The Colon
Developmental And Epileptic Encephalopathy 76

  • DEE76

  • Epileptic Encephalopathy, Early Infantile, 76

  • Eiee76

  • Decam

  • Developmental And Epileptic Encephalopathy, 76

  • Developmental Delay, Epileptic Encephalopathy, Cerebral Atrophy, And Abnormal Myelination

  • Developmental Delay, Epileptic Endephalopathy, Cerebral Atrophy, And Abnormal Myelination

  • Early Infantile Epileptic Encephalopathy 76
Cholangiolocellular Carcinoma
Ovarian Mucinous Adenocarcinoma

  • Mucinous Carcinoma Of Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70164 Carbohydrate Sulfotransferase 4 / Unkown
HY-RS02690 CHST4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CHST4 MGD MGI:1349479
Macaca mulatta CHST4 VGNC VGNC:71057
Felis catus CHST4 VGNC VGNC:60891
Bos taurus CHST4 VGNC VGNC:27346
Rattus norvegicus CHST4 RGD RGD:1310798
Canis familiaris CHST4 VGNC VGNC:39256
Others CHST4 NCBI