ROCK1 - Rho associated coiled-coil containing protein kinase 1 Gene

Species: Macaca fascicularis

Gene Type: protein coding
Gene ID: 102140851

About ROCK1

Primary_assembly 18: 60,549,133-60,708,018 forward strand.Macaca_fascicularis_6.0:CM021956.1

This gene has 2 transcripts (splice variants), 212 orthologues and 5 paralogues.

ROCK1 Products (3)

mRNA Protein Name
XM_005587068.3 XP_005587125.1 rho-associated protein kinase 1 isoform X2
XM_045377988.1 XP_045233923.1 rho-associated protein kinase 1 isoform X3
XM_005587067.2 XP_005587124.1 rho-associated protein kinase 1 isoform X1

ROCK1 Protein Structure

STKc_ROCK1

STKc_ROCK1: cd05622 (1 - 405)

SbcC

SbcC: COG0419 (421 - 963)

HR1_ROCK1

HR1_ROCK1: cd11639 (488 - 553)

ROCK_SBD

ROCK_SBD: cd22250 (835 - 912)

Rho_Binding

Rho_Binding: pfam08912 (948 - 1013)

ROCK_SBD

ROCK_SBD: cl40587 (1001 - 1057)

PH_ROCK

PH_ROCK: cd01242 (1118 - 1224)

C1_ROCK1

C1_ROCK1: cd20874 (1221 - 1289)

  • 0
  • 300
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  • 900
  • 1200
  • 1354 a.a.
Protein Preferred Names Protein Names

rho-associated protein kinase 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10583 Y-27632 dihydrochloride Inhibitor 99.98% Unkown
HY-10341 Fasudil Hydrochloride Inhibitor 99.97% Yes
HY-15307 Belumosudil Inhibitor 99.83% Yes
HY-10341A Fasudil Inhibitor 99.98% Yes
HY-15685 Ripasudil Inhibitor 99.95% Unkown
HY-15307A Belumosudil mesylate Inhibitor 99.89% Yes
HY-13911A Hydroxyfasudil hydrochloride Inhibitor 98.88% Unkown
HY-13911 Hydroxyfasudil Inhibitor 98.78% Unkown
HY-10341C Fasudil dihydrochloride Inhibitor 99.98% Yes
HY-10341B Fasudil hydrochloride semihydrate Inhibitor / Unkown
HY-15685A Ripasudil free base Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-109191 Sovesudil Inhibitor 99.91% Phase 3
HY-109191A Sovesudil hydrochloride Inhibitor 99.45% Phase 3
HY-15687A SAR407899 Inhibitor 99.67% Phase 2
HY-15687 SAR407899 hydrochloride Inhibitor 99.14% Phase 2
HY-16758 Verosudil Inhibitor 98.22% Phase 2
HY-16758A Verosudil hydrochloride Inhibitor / Phase 2
HY-16071 AT13148 Inhibitor 99.20% Phase 1

Pre-clinical Phase

Bioactive Molecules (39)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10071 Y-27632 Inhibitor 99.91% Unkown
HY-15392 Chroman 1 Inhibitor 98.97% Unkown
HY-15556 GSK269962A Inhibitor 99.75% Unkown
HY-11000 GSK429286A Inhibitor 98.27% Unkown
HY-119937 ROCK inhibitor-2 Inhibitor 99.92% Unkown
HY-15755 RKI-1447 Inhibitor 98.02% Unkown
HY-13300 SR-3677 Inhibitor 99.23% Unkown
HY-10319 BAY-549 Inhibitor 99.46% Unkown
HY-108518 SB-772077B dihydrochloride Inhibitor 99.33% Unkown
HY-15392A Chroman 1 dihydrochloride Inhibitor 98.13% Unkown
HY-12437 BDP5290 Inhibitor 98.90% Unkown
HY-18990 GSK180736A Inhibitor 98.81% Unkown
HY-15556A GSK269962A hydrochloride Inhibitor 99.73% Unkown
HY-162596 NRL-1049 Inhibitor 99.96% Unkown
HY-132302 Hu7691 Inhibitor 99.91% Unkown
HY-14362 GSK-25 Inhibitor 98.33% Unkown
HY-149266 THK01 Inhibitor 99.80% Unkown
HY-110339 RKI-1447 dihydrochloride Inhibitor 99.94% Unkown
HY-Q22471 ROCK1-IN-1 Inhibitor 99.14% Unkown
HY-100270 Rho-Kinase-IN-1 Inhibitor 99.91% Unkown
HY-125221 DJ4 Inhibitor 99.25% Unkown
HY-126275 HSD1590 Inhibitor 99.00% Unkown
HY-14227 LIMK-IN-1 Inhibitor 99.33% Unkown
HY-122011 PF-4950834 Inhibitor 99.60% Unkown
HY-178821 ROCK2-IN-12 Inhibitor 98.02% Unkown
HY-N12378 β-Patchoulene Inhibitor 96.88% Unkown
HY-107209 RKI-1313 Inhibitor 98.2% Unkown
HY-172177 ROCK/HDAC-IN-2 Inhibitor / Unkown
HY-132302A Hu7691 free base Inhibitor / Unkown
HY-13300A SR-3677 dihydrochloride Inhibitor / Unkown
HY-181582 LASSBio-2382 Inhibitor / Unkown
HY-W047432 5-Nitro-1H-indazole-3-carbonitrile Inhibitor / Unkown
HY-178013 ROCK2-IN-11 Inhibitor / Unkown
HY-175843 ROCK2-IN-10 Inhibitor / Unkown
HY-164809 Desisopropyle-belumosudil Inhibitor / Unkown
HY-181583 LASSBio-2389 Inhibitor / Unkown
HY-168650 ROCK/HDAC-IN-1 Inhibitor / Unkown
HY-N15301 Nocarnickelamide B Inhibitor / Unkown
HY-123939 JAK1/3-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ROCK1 NCBI NCBI:6093