Cd276 - CD276 antigen Gene

Also Known as B7h3; B7RP-2; 6030411F23Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 102657

Summary

Enables identical protein binding activity and signaling receptor binding activity. Acts upstream of or within several processes, including positive regulation of osteoblast differentiation; regulation of T cell proliferation; and regulation of cytokine production. Located in external side of plasma membrane. Is expressed in several structures, including embryo endoderm; genitourinary system; hemolymphoid system; liver; and musculoskeletal system. Orthologous to human CD276 (CD276 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd276 Products (1)

mRNA	Protein	Name
NM_133983.4	NP_598744.1	CD276 antigen precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	23583036	MGI
enables signaling receptor binding	IDA IDA: Inferred from direct assay	12055244	MGI
enables signaling receptor binding	IMP IMP: Inferred from mutant phenotype	12925852	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of T cell proliferation	IDA IDA: Inferred from direct assay	12925852	MGI
acts upstream of T cell proliferation	IMP IMP: Inferred from mutant phenotype	12925852	MGI
acts upstream of or within negative regulation of T cell proliferation	IDA IDA: Inferred from direct assay	12925852	MGI
acts upstream of or within negative regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	12925852	MGI
acts upstream of or within negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	12925852	MGI
acts upstream of or within negative regulation of interleukin-2 production	IDA IDA: Inferred from direct assay	12925852	MGI
acts upstream of or within negative regulation of type II interferon production	IDA IDA: Inferred from direct assay	12925852	MGI
acts upstream of or within negative regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	12925852	MGI
acts upstream of or within positive regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	16751379	MGI
acts upstream of or within positive regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	15317945	MGI
acts upstream of or within positive regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	16751379	MGI
acts upstream of or within positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	15317945	MGI
acts upstream of or within regulation of immune response	IMP IMP: Inferred from mutant phenotype	12925852	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	12925852	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
CD276 antigen	B7 homolog 3 B7-H3 costimulatory molecule

Cd276 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Cd276	Q8VE98	Cd276	Mus musculus	Q8VE98	GMS	23583036
Intra	Cd276	Q8VE98	Cd276	Mus musculus	Q8VE98	X-Ray Diffraction	23583036

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Cd276 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7639	CD276/B7-H3 Protein, Mouse (HEK293, His)	Q8VE98 (V29-F244)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145636	Vobramitamab duocarmazine		99.31%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99157	Omburtamab	Inhibitor	99.16%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02220	CD276 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17006	Cd276 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23449	Cd276 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990279	Anti-Mouse CD276/B7-H3 Antibody (MJ18)		95.00%	Unkown
HY-P99740	Mirzotamab	Inhibitor	99.45%	Unkown
HY-P992110	Elfetabart	Inhibitor	98.31%	Unkown
HY-P992158	VBI-009		/	Unkown
HY-P990340	Anti-B7-H3/CD276 Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cd276	NCBI	NCBI:80381