Acaca - acetyl-Coenzyme A carboxylase alpha Gene

Also Known as Acac; Acc1; Gm738; A530025K05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 107476

About Acaca

Chromosome 11: 84,020,498-84,292,477 forward strand.GRCm39:CM001004.3

This gene has 9 transcripts (splice variants), 205 orthologues, 4 paralogues and is associated with 5 phenotypes. Broad expression in mammary gland adult (RPKM 81.6), subcutaneous fat pad adult (RPKM 79.2) and 17 other tissues.

Summary

Enables Acetyl-CoA Carboxylase activity. Involved in acetyl-CoA metabolic process; fatty acid biosynthetic process; and protein homotetramerization. Acts upstream of or within several processes, including cellular response to prostaglandin E stimulus; lipid homeostasis; and tissue homeostasis. Located in cytosol. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human ACACA (Acetyl-CoA Carboxylase alpha). [provided by Alliance of Genome Resources, Apr 2022]

Acaca Products (1)

mRNA Protein Name
NM_133360.3 NP_579938.2 acetyl-CoA carboxylase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables acetyl-CoA carboxylase activity IDA
IDA: Inferred from direct assay
20952656 MGI
enables acetyl-CoA carboxylase activity IGI
IGI: Inferred from genetic interaction
17210641 MGI
enables acetyl-CoA carboxylase activity IMP
IMP: Inferred from mutant phenotype
8954960 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20457939 MGI
Biological Process GO Annotation Evidence Références Source
involved in acetyl-CoA metabolic process IDA
IDA: Inferred from direct assay
20952656 MGI
acts upstream of or within cellular response to prostaglandin E stimulus IDA
IDA: Inferred from direct assay
23479225 MGI
involved in fatty acid biosynthetic process IDA
IDA: Inferred from direct assay
20952656 MGI
involved in lipid biosynthetic process IGI
IGI: Inferred from genetic interaction
17210641 MGI
involved in lipid biosynthetic process IMP
IMP: Inferred from mutant phenotype
16717184 MGI
acts upstream of or within lipid homeostasis IMP
IMP: Inferred from mutant phenotype
17210641 MGI
acts upstream of or within lipid metabolic process IMP
IMP: Inferred from mutant phenotype
17210641 MGI
involved in protein homotetramerization IDA
IDA: Inferred from direct assay
20952656 MGI
acts upstream of or within protein metabolic process IMP
IMP: Inferred from mutant phenotype
17210641 MGI
acts upstream of or within tissue homeostasis IMP
IMP: Inferred from mutant phenotype
17210641 MGI
Cellular Component GO Annotation Evidence Références Source
is active in cytosol IDA
IDA: Inferred from direct assay
16717184 MGI
located in cytosol IDA
IDA: Inferred from direct assay
20952656 MGI
is active in cytosol IGI
IGI: Inferred from genetic interaction
17210641 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Acaca Protein Structure

AccC

AccC: COG0439 (116 - 618)

AccB

AccB: cl33922 (669 - 816)

Biotin_lipoyl

Biotin_lipoyl: pfam00364 (751 - 816)

ACC_central

ACC_central: pfam08326 (818 - 1567)

Carboxyl_trans

Carboxyl_trans: pfam01039 (1667 - 2215)

  • 0
  • 400
  • 800
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  • 1600
  • 2000
  • 2345 a.a.
Protein Preferred Names Protein Names

acetyl-CoA carboxylase 1

  • ACC-alpha

  • acetyl-CoA carboxylase 265

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS00119 ACACA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00120 Acaca Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00121 Acaca Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acaca NCBI NCBI:31