Grm6 - glutamate receptor, metabotropic 6 Gene

Also Known as Gm3; nob2; nob3; nob4; nerg1; Gprc1f; mGluR6

Species: Mus musculus

Gene Type: protein coding
Gene ID: 108072

About Grm6

Chromosome 11: 50,741,512-50,757,035 forward strand.GRCm39:CM001004.3

This gene has 4 transcripts (splice variants), 250 orthologues, 7 paralogues and is associated with 20 phenotypes. Low expression observed in reference dataset.

Summary

Predicted to enable Adenylate Cyclase inhibiting G protein-coupled glutamate receptor activity and protein homodimerization activity. Involved in locomotory behavior and sensory perception of light stimulus. Acts upstream of or within retina development in camera-type eye and signal transduction. Located in new growing cell tip. Is expressed in prostate gland; retina inner nuclear layer; and testis. Used to study congenital stationary night blindness 1B. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1B. Orthologous to human GRM6 (glutamate metabotropic receptor 6). [provided by Alliance of Genome Resources, Apr 2022]

Grm6 Products (1)

mRNA Protein Name
NM_173372.2 NP_775548.2 metabotropic glutamate receptor 6 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
36179691 MGI
involved in locomotory behavior IMP
IMP: Inferred from mutant phenotype
10842024 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
21052544 MGI
involved in sensory perception of light stimulus IMP
IMP: Inferred from mutant phenotype
10842024 MGI
acts upstream of or within signal transduction IGI
IGI: Inferred from genetic interaction
19966281 MGI
acts upstream of or within synapse assembly IMP
IMP: Inferred from mutant phenotype
36179691 MGI
Cellular Component GO Annotation Evidence References Source
is active in cell tip IDA
IDA: Inferred from direct assay
25997951 MGI
is active in dendrite IDA
IDA: Inferred from direct assay
25997951 MGI
located in new growing cell tip IDA
IDA: Inferred from direct assay
19966281 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Grm6 Protein Structure

PBP1_mGluR_groupIII

PBP1_mGluR_groupIII: cd06376 (38 - 499)

NCD3G

NCD3G: pfam07562 (507 - 557)

7tm_GPCRs

7tm_GPCRs: cl28897 (577 - 849)

7tm_GPCRs

7tm_GPCRs: cd14964 (578 - 602)

7tm_GPCRs

7tm_GPCRs: cd14964 (614 - 635)

7tm_GPCRs

7tm_GPCRs: cd14964 (644 - 666)

7tm_GPCRs

7tm_GPCRs: cd14964 (692 - 708)

7tm_GPCRs

7tm_GPCRs: cd14964 (740 - 763)

7tm_GPCRs

7tm_GPCRs: cd14964 (775 - 797)

7tm_GPCRs

7tm_GPCRs: cd14964 (807 - 832)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 871 a.a.
Protein Preferred Names Protein Names

metabotropic glutamate receptor 6

  • G protein-coupled receptor GRM6

  • G protein-coupled receptor, family C, group 1, member F

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05834 GRM6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05835 Grm6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05836 Grm6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grm6 NCBI NCBI:2916