FGL2 - fibrinogen like 2 Gene

Also Known as T49; pT49

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10875

About FGL2

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:77,193,369-77,199,819 (from NCBI)

This gene has 2 transcripts (splice variants), 278 orthologues and 25 paralogues. Broad expression in spleen (RPKM 83.3), appendix (RPKM 61.0) and 22 other tissues.

Summary

The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008]

FGL2 Products (1)

mRNA Protein Name
NM_006682.3 NP_006673.1 fibroleukin precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
35156780 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGL2 Protein Structure

Fibrinogen_C

Fibrinogen_C: Fibrinogen beta and gamma chains, C-terminal globular domain (210 - 435)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 439 a.a.
Protein Preferred Names Protein Names

fibroleukin

  • fibrinogen-like protein 2

FGL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FGL2 Q14314 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FGL2 Proteins

Cat. No. Product Name Accession Purity
HY-P700721 FGL2 Protein, Human (HEK293, His-Avi, Flag) Q14314 (V205-P439) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P700987 FGL2 Protein, Human (Biotinylated, HEK293, His-Avi, Flag) Q14314 (V205-P439) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P701078 FGL2 Protein, Human (HEK293, hFc-Flag) Q14314 (V205-P439) ≥ 90%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases Alias
Viral Hepatitis

  • Animal Viral Hepatitis

  • Hepatitis, Viral, Animal

  • Human Viral Hepatitis

  • Viral Hepatitis With Hepatic Coma
Hepatitis B

  • Chronic Hepatitis B

  • Hepatitis B Infection

  • Serum Hepatitis

  • HBV

  • Hepatitis B Chronic

  • Hbv, Susceptibility To

  • Hepatitis B, Chronic

  • Chronic Hepatitis B Without Delta Agent

  • Chronic Hbv - [Hepatitis B Virus] Infection

  • Hepatitis B Nos

  • Chronic Type B Viral Hepatitis

  • Hep B Nos
Ileum Cancer

  • Ileal Neoplasm

  • Malignant Neoplasm Of Ileum

  • Ileal Cancer

  • Ileal Neoplasms
Autoimmune Glomerulonephritis
Pontocerebellar Hypoplasia, Type 3

  • Pontocerebellar Hypoplasia Type 3

  • Cerebellar Atrophy With Progressive Microcephaly

  • PCH3

  • Clam

  • Pch With Optic Atrophy

  • Pontocerebellar Hypoplasia 3

  • Hypoplasia, Pontocerebellar, Type 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04928 FGL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18756 Fgl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25243 Fgl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FGL2 VGNC VGNC:80044
Rattus norvegicus FGL2 RGD RGD:620170
Mus musculus FGL2 MGD MGI:103266
Macaca mulatta FGL2 VGNC VGNC:72657
Bos taurus FGL2 VGNC VGNC:28993
Canis familiaris FGL2 VGNC VGNC:40865
Others FGL2 NCBI