Ampd2 - adenosine monophosphate deaminase 2 Gene

Also Known as Ampd-2; m4521Dajl; 1200014F01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 109674

Summary

Enables AMP deaminase activity. Involved in ATP metabolic process and purine ribonucleotide metabolic process. Acts upstream of or within several processes, including IMP biosynthetic process; Cholesterol homeostasis; and energy homeostasis. Predicted to be active in cytosol. Is expressed in several structures, including endocrine gland; genitourinary system; nervous system; and vascular system. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 63 and pontocerebellar hypoplasia type 9. Orthologous to human AMPD2 (adenosine monophosphate deaminase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ampd2 Products (4)

mRNA Protein Name
NM_001289719.1 NP_001276648.1 AMP deaminase 2 isoform b
NM_001289720.1 NP_001276649.1 AMP deaminase 2 isoform a
NM_001346665.1 NP_001333594.1 AMP deaminase 2 isoform d
NM_028779.5 NP_083055.1 AMP deaminase 2 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables AMP deaminase activity IMP
IMP: Inferred from mutant phenotype
22212473 MGI
Biological Process GO Annotation Evidence References Source
involved in AMP metabolic process IMP
IMP: Inferred from mutant phenotype
22212473 MGI
involved in ATP metabolic process IGI
IGI: Inferred from genetic interaction
23911318 MGI
involved in ATP metabolic process IMP
IMP: Inferred from mutant phenotype
22212473 MGI
involved in GTP metabolic process IGI
IGI: Inferred from genetic interaction
23911318 MGI
involved in GTP metabolic process IMP
IMP: Inferred from mutant phenotype
22212473 MGI
acts upstream of or within IMP biosynthetic process IMP
IMP: Inferred from mutant phenotype
23911318 MGI
involved in IMP salvage IMP
IMP: Inferred from mutant phenotype
22212473 MGI
acts upstream of or within cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
18974039 MGI
acts upstream of or within energy homeostasis IMP
IMP: Inferred from mutant phenotype
23911318 MGI
acts upstream of or within nucleotide metabolic process IMP
IMP: Inferred from mutant phenotype
22212473 MGI
acts upstream of or within podocyte development IMP
IMP: Inferred from mutant phenotype
25361754 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

AMP deaminase 2

  • adenosine monophosphate deaminase 2 (isoform L)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103673 AMPD2 inhibitor 1 Inhibitor 99.52% Unkown
HY-152199 AMPD2 inhibitor 2 Inhibitor / Unkown
HY-RS00667 AMPD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18984 Ampd2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25473 Ampd2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ampd2 NCBI NCBI:271