Rap1a - RAS-related protein 1a Gene

Also Known as Rap1; G-22K; Krev-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 109905

Summary

Enables GTPase activity and small GTPase binding activity. Involved in positive regulation of vasculogenesis. Acts upstream of or within several processes, including negative regulation of synaptic vesicle exocytosis; positive regulation of ERK1 and ERK2 cascade; and positive regulation of neuron projection development. Located in several cellular components, including cell junction; neuron projection; and plasma membrane. Part of guanyl-nucleotide exchange factor complex. Is expressed in brain; early conceptus; hemolymphoid system gland; and oocyte. Orthologous to human RAP1A (RAP1A, member of Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Rap1a Products (1)

mRNA Protein Name
NM_145541.5 NP_663516.1 ras-related protein Rap-1A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activity IDA
IDA: Inferred from direct assay
12473665 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14712229 MGI
enables small GTPase binding IPI
IPI: Inferred from physical interaction
15894621 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of synaptic vesicle exocytosis IGI
IGI: Inferred from genetic interaction
23616533 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
23616533 MGI
acts upstream of or within positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
22732430 MGI
involved in positive regulation of vasculogenesis IMP
IMP: Inferred from mutant phenotype
19635461 MGI
acts upstream of or within small GTPase-mediated signal transduction IDA
IDA: Inferred from direct assay
12473665 MGI
acts upstream of synaptic vesicle exocytosis IGI
IGI: Inferred from genetic interaction
23616533 MGI
Cellular Component GO Annotation Evidence References Source
located in cell junction IDA
IDA: Inferred from direct assay
19635461 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
22732430 MGI
part of guanyl-nucleotide exchange factor complex IDA
IDA: Inferred from direct assay
15894621 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
22732430 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17403904 MGI
located in sperm midpiece IDA
IDA: Inferred from direct assay
30360518 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ras-related protein Rap-1A

  • GTP-binding protein SMG-P21A

  • ras-related protein Krev-1

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16322 Minodronic acid 99.67% Unkown

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15871 GGTI298 Trifluoroacetate Inducer 99.87% Unkown
HY-123242 FTI-2153 Inhibitor 99.77% Unkown
HY-12369 GGTI-2133 Inhibitor 98.50% Unkown
HY-115489A GGTI-286 TFA Inhibitor / Unkown
HY-115489 GGTI-286 Inhibitor / Unkown
HY-100876 GGTI298 Inducer / Unkown
HY-117935 GGTI-286 hydrochloride Inhibitor / Unkown
HY-123242A FTI-2153 TFA Inhibitor 98.41% Unkown
HY-RS16300 Rap1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-120229 GGTI-2147 Inhibitor / Unkown
HY-12369A GGTI-2133 TFA Inhibitor / Unkown
HY-RS11652 RAP1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-120271 GGTI-297 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rap1a NCBI NCBI:5906