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Flt4 - Fms related receptor tyrosine kinase 4 Gene

Also Known as Vegfr3

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 114110

About Flt4

Primary_assembly 10: 33,913,608-33,954,770 forward strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 196 orthologues, 54 paralogues and is associated with 14 phenotypes. Biased expression in Adrenal (RPKM 182.8), Lung (RPKM 61.9) and 7 other tissues.

Summary

Enables growth factor binding activity and vascular endothelial growth factor-activated receptor activity. Involved in positive regulation of cell growth and vascular endothelial growth factor receptor signaling pathway. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Orthologous to human FLT4 (fms related receptor tyrosine kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Flt4 Products (1)

mRNA	Protein	Name
NM_053652.2	NP_446104.2	vascular endothelial growth factor receptor 3 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables growth factor binding	IMP IMP: Inferred from mutant phenotype	11683876	RGD
enables vascular endothelial growth factor receptor activity	IMP IMP: Inferred from mutant phenotype	11683876	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of cell growth	IDA IDA: Inferred from direct assay	7898938	RGD
involved in vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11683876	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Flt4 Protein Structure

Ig_2

IgI_VEGFR

IG_like

VEGFR-2_TMD

PKc_like

0
300
600
900
1200
1363 a.a.

Protein Preferred Names	Protein Names
vascular endothelial growth factor receptor 3	FLT-4 FMS-like tyrosine kinase 4 VEGFR-3 fms-related tyrosine kinase 4 tyrosine-protein kinase receptor FLT4

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-10260	Vandetanib	99.85%	Yes
HY-10260B	Vandetanib hydrochloride	/	Unkown
HY-10260A	Vandetanib trifluoroacetate	/	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10205	Cediranib		99.87%	Phase 3
HY-100019	Rogaratinib	Inhibitor	99.86%	Phase 3
HY-13034	Gandotinib	Inhibitor	99.86%	Phase 2
HY-10987	ENMD-2076 Tartrate		99.66%	Phase 2

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116624	MAZ51		99.96%	Unkown
HY-10987A	ENMD-2076		99.99%	Unkown
HY-15813	FIIN-1	Inhibitor	99.04%	Unkown
HY-13049	Cediranib maleate		99.68%	Yes
HY-119933	RIPK1-IN-7	Inhibitor	98.56%	Unkown
HY-145293	TNIK-IN-3	Inhibitor	99.79%	Unkown
HY-RS04994	FLT4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-10260S	Vandetanib-d6		/	Unkown
HY-10260S1	Vandetanib-d4		/	Unkown
HY-10260S2	Vandetanib-13C6		/	Unkown
HY-110272	Vatalanib succinate	Inhibitor	/	Unkown
HY-155178	Antiproliferative agent-34	Inhibitor	/	Unkown
HY-168114	Multi-kinase inhibitor 3	Inhibitor	/	Unkown
HY-168115	Multi-kinase inhibitor 4	Inhibitor	/	Unkown
HY-173124	CDK2/FLT4/PDGFRA-IN-1		/	Unkown
HY-182354	VEGFR2-IN-84	Inhibitor	/	Unkown
HY-RS04995	Flt4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04996	Flt4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174683	Human FLT4 mRNA		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990620	LY3022856	Inhibitor	98.84%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Flt4	NCBI	NCBI:2324