Asic1 - acid-sensing (proton-gated) ion channel 1 Gene

Also Known as ASIC; Accn2; BNaC2; ASIC1a; ASIC1b; B530003N02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11419

Summary

Enables acid-sensing ion channel activity and ion gated channel activity. Acts upstream of or within several processes, including behavioral fear response; learning or memory; and response to amphetamine. Located in synapse. Is integral component of plasma membrane. Is expressed in several structures, including brain. Orthologous to human ASIC1 (acid sensing ion channel subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Asic1 Products (2)

mRNA Protein Name
NM_001289791.2 NP_001276720.1 acid-sensing ion channel 1 isoform 2
NM_009597.2 NP_033727.1 acid-sensing ion channel 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables monoatomic cation channel activity IDA
IDA: Inferred from direct assay
11854527 MGI
enables monoatomic cation channel activity IMP
IMP: Inferred from mutant phenotype
11854527 MGI
enables monoatomic ion-gated channel activity IDA
IDA: Inferred from direct assay
14960591 MGI
enables monoatomic ion-gated channel activity IMP
IMP: Inferred from mutant phenotype
14960591 MGI
enables pH-gated monoatomic ion channel activity IDA
IDA: Inferred from direct assay
21036899 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18287010 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within associative learning IMP
IMP: Inferred from mutant phenotype
11988176 MGI
acts upstream of or within behavioral fear response IMP
IMP: Inferred from mutant phenotype
25828470 MGI
acts upstream of or within calcium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
19376200 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
14960591 MGI
acts upstream of or within memory IMP
IMP: Inferred from mutant phenotype
11988176 MGI
acts upstream of or within monoatomic cation transport IDA
IDA: Inferred from direct assay
11854527 MGI
acts upstream of or within monoatomic cation transport IMP
IMP: Inferred from mutant phenotype
11854527 MGI
acts upstream of or within monoatomic ion transmembrane transport IDA
IDA: Inferred from direct assay
14960591 MGI
acts upstream of or within monoatomic ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
14960591 MGI
acts upstream of or within negative regulation of neurotransmitter secretion IMP
IMP: Inferred from mutant phenotype
18094106 MGI
acts upstream of neurotransmitter secretion IMP
IMP: Inferred from mutant phenotype
18094106 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
19376200 MGI
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
17060608 MGI
involved in regulation of postsynapse assembly IMP
IMP: Inferred from mutant phenotype
17060608 MGI
acts upstream of or within response to acidic pH IDA
IDA: Inferred from direct assay
11854527 MGI
acts upstream of or within response to acidic pH IMP
IMP: Inferred from mutant phenotype
11854527 MGI
acts upstream of or within response to amphetamine IMP
IMP: Inferred from mutant phenotype
25828470 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17060608 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
17060608 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
21036899 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11854527 MGI
located in synapse IDA
IDA: Inferred from direct assay
11988176 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

acid-sensing ion channel 1

  • amiloride-sensitive cation channel 2, neuronal

  • brain sodium channel 2

  • degenerin 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1411 Psalmotoxin 1 99.20% Unkown
HY-131879 NS383 99.83% Unkown
HY-164284 LK-2 Antagonist 98.83% Unkown
HY-P5174 MitTx Activator 98.0% Unkown
HY-176550 ASIC1a antagonist-1 Antagonist 98.00% Unkown
HY-P1411A Psalmotoxin 1 TFA 99.37% Unkown
HY-P1441A Mambalgin 1 TFA Inhibitor 95.72% Unkown
HY-131261 Ibuprofen alcohol / Unkown
HY-155017 6-Iodoamiloride Inhibitor / Unkown
HY-P10977 Tat-ASIC1a (1-20) (mouse, rat) Inhibitor / Unkown
HY-P5172 MitTx-alpha Agonist / Unkown
HY-P5780 π-TRTX-Hm3a Inhibitor / Unkown
HY-P5899 Mambalgin-3 Inhibitor / Unkown
HY-RS01089 ASIC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W703632 2-(4-Isobutylphenyl)propan-3,3,3-d3-1-ol / Unkown
HY-RS17600 Asic1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24060 Asic1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Asic1 NCBI NCBI:41