2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. π-TRTX-Hm3a

π-TRTX-Hm3a is a 37-amino acid peptide isolated from Togo starburst tarantula (Heteroscodra maculata) venom. π-TRTX-Hm3a pH-dependently inhibits acid-sensing ion channel 1a (ASIC1a) with an IC50 of 1-2 nM and potentiates ASIC1b with an EC50 of 46.5 nM.

For research use only. We do not sell to patients.

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π-TRTX-Hm3a Chemical Structure

π-TRTX-Hm3a Chemical Structure

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π-TRTX-Hm3a Related Antibodies

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Description

π-TRTX-Hm3a is a 37-amino acid peptide isolated from Togo starburst tarantula (Heteroscodra maculata) venom. π-TRTX-Hm3a pH-dependently inhibits acid-sensing ion channel 1a (ASIC1a) with an IC50 of 1-2 nM and potentiates ASIC1b with an EC50 of 46.5 nM[1].

Molecular Weight

4287.03

Formula

C186H290N56O49S6
Sequence

Glu-Pro-Cys-Ile-Pro-Lys-Trp-Lys-Ser-Cys-Val-Asn-Arg-His-Gly-Asp-Cys-Cys-Ala-Gly-Leu-Glu-Cys-Trp-Lys-Arg-Arg-Lys-Ser-Phe-Glu-Val-Cys-Val-Pro-Lys-Val (Disulfide bridge:Cys3-Cys18;Cys10-Cys23;Cys17-Cys33)
Sequence Shortening

EPCIPKWKSCVNRHGDCCAGLECWKRRKSFEVCVPKV (Disulfide bridge:Cys3-Cys18;Cys10-Cys23;Cys17-Cys33)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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π-TRTX-Hm3a Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

π-TRTX-Hm3aSodium ChannelNa channelsNa+ channelsASIC1aASIC1bvenomInhibitorinhibitorinhibit

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