Klf4 - KLF transcription factor 4 Gene

Also Known as GKLF

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 114505

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and phosphatidylinositol 3-kinase regulator activity. Involved in several processes, including cellular response to organonitrogen compound; negative regulation of intracellular signal transduction; and regulation of transcription, DNA-templated. Located in chromatin and nucleus. Part of transcription regulator complex. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human KLF4 (Kruppel like factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Klf4 Products (1)

mRNA	Protein	Name
NM_053713.1	NP_446165.1	Krueppel-like factor 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17659301	RGD
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12034813	RGD
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	12034813	RGD
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	19486889	RGD
enables phosphatidylinositol 3-kinase regulator activity	IMP IMP: Inferred from mutant phenotype	19531492	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12034813	RGD
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19531492	RGD
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	21252119	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to cycloheximide	IEP IEP: Inferred from expression pattern	18406357	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	18406357	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18406357	RGD
involved in cellular response to peptide	IEP IEP: Inferred from expression pattern	18406357	RGD
involved in cellular response to retinoic acid	IEP IEP: Inferred from expression pattern	19486889	RGD
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19531492	RGD
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	19531492	RGD
involved in negative regulation of muscle hyperplasia	IMP IMP: Inferred from mutant phenotype	19531492	RGD
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	19531492	RGD
involved in negative regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	17659301	RGD
involved in negative regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	19531492	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12034813	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	15632413	RGD
part of transcription regulator complex	IDA IDA: Inferred from direct assay	15632413	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
Krueppel-like factor 4	Kruppel like factor 4 Kruppel-like factor 4 (gut)

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16291	APTO-253		99.74%	Phase 1
HY-16291A	APTO-253 hydrochloride	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12302	Kenpaullone	Inhibitor	98.20%	Unkown
HY-W072962	WX2-43		98.74%	Unkown
HY-RS07341	KLF4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16607	Klf4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-121917	Ro 31-7837		/	Unkown
HY-131923	DAPM	Inhibitor	/	Unkown
HY-174592	Human KLF4 mRNA		/	Unkown
HY-RS23041	Klf4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Klf4	NCBI	NCBI:9314