Aurkb - aurora kinase B Gene

Also Known as Aim1; ARK-2; STK-1; Stk12

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114592

About Aurkb

Primary_assembly 10: 53,745,142-53,750,837 forward strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 217 orthologues, 2 paralogues and is associated with 11 phenotypes. Biased expression in Thymus (RPKM 175.8), Lung (RPKM 119.5) and 8 other tissues.

Summary

Enables protein kinase activity. Involved in aging; cell population proliferation; and cleavage furrow formation. Located in midbody and spindle. Orthologous to human AURKB (Aurora Kinase B). [provided by Alliance of Genome Resources, Apr 2022]

Aurkb Products (1)

mRNA Protein Name
NM_053749.2 NP_446201.1 aurora kinase B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein kinase activity IMP
IMP: Inferred from mutant phenotype
9450992 RGD
Biological Process GO Annotation Evidence References Source
involved in cleavage furrow formation IMP
IMP: Inferred from mutant phenotype
9450992 RGD
Cellular Component GO Annotation Evidence References Source
located in midbody IDA
IDA: Inferred from direct assay
9450992 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Aurkb Protein Structure

STKc_Aurora-B_like

STKc_Aurora-B_like: cd14117 (74 - 341)

  • 0
  • 100
  • 200
  • 300
  • 343 a.a.
Protein Preferred Names Protein Names

aurora kinase B

  • AIM-1

  • aurora 1

  • aurora- and Ipl1-like midbody-associated protein 1

  • aurora-B

  • aurora-related kinase 2

  • aurora/IPL1-related kinase 2

  • serine/threonine kinase 12

  • serine/threonine-protein kinase 12

  • serine/threonine-protein kinase 5

  • serine/threonine-protein kinase aurora-B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-151971 Aurora kinase-IN-3 Inhibitor 99.02% Unkown
HY-168543 PROTAC AURKA degrader 3 Degrader 99.78% Unkown
HY-137344A dAURK-4 hydrochloride Degrader 98.14% Unkown
HY-175525 MS44 Degrader 99.89% Unkown
HY-157480 EGFR/AURKB-IN-1 Inhibitor 99.43% Unkown
HY-168540 PROTAC MPS1 degrader 1 99.90% Unkown
HY-180132 PROTAC AURKA degrader 2 Degrader 98.36% Unkown
HY-168545 SF-1 Ligand 99.50% Unkown
HY-RS01270 AURKB Human Pre-designed siRNA Set A / Unkown
HY-10338A Foretinib phosphate Inhibitor / Unkown
HY-116190 CFI-401870 Inhibitor / Unkown
HY-120279A CFI-400437 Inhibitor / Unkown
HY-123610 BRD-7880 Inhibitor / Unkown
HY-137344 dAURK-4 Degrader 99.93% Unkown
HY-175526 Aurora kinase ligand-1 / Unkown
HY-176191 Aurora kinase-IN-7 Inhibitor / Unkown
HY-184329 PROTAC AURKB Degrader-1 / Unkown
HY-N17821 Butrin / Unkown
HY-RS01271 Aurkb Mouse Pre-designed siRNA Set A / Unkown
HY-RS01272 Aurkb Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aurkb NCBI NCBI:9212