Cdkn1a - cyclin-dependent kinase inhibitor 1A Gene

Also Known as Cip1; UV96; Waf1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 114851

About Cdkn1a

Primary_assembly 20: 7,149,217-7,159,585 forward strand.mRatBN7.2:CM026993.1

This gene has 2 transcripts (splice variants), 196 orthologues, 2 paralogues and is associated with 90 phenotypes. Biased expression in Heart (RPKM 69.9), Muscle (RPKM 65.1) and 9 other tissues.

Summary

Predicted to enable several functions, including cyclin binding activity; enzyme binding activity; and protein kinase regulator activity. Involved in several processes, including intestinal epithelial cell maturation; response to corticosterone; and response to hyperoxia. Located in nucleus and perinuclear region of cytoplasm. Biomarker of autosomal dominant polycystic kidney disease; hypertension (multiple); lipoid nephrosis; liver benign neoplasm; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in several diseases, including lung non-small cell carcinoma; ocular hypertension; oral mucosa leukoplakia; oral squamous cell carcinoma; and primary open angle glaucoma. Orthologous to human CDKN1A (cyclin dependent kinase inhibitor 1A). [provided by Alliance of Genome Resources, Apr 2022]

Cdkn1a Products (1)

mRNA Protein Name
NM_080782.4 NP_542960.1 cyclin-dependent kinase inhibitor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19533683 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
8651753 RGD
Biological Process GO Annotation Evidence References Source
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
17427960 RGD
involved in cellular response to heat IEP
IEP: Inferred from expression pattern
11295070 RGD
involved in intestinal epithelial cell maturation IEP
IEP: Inferred from expression pattern
20466941 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
17617061 RGD
involved in response to X-ray IEP
IEP: Inferred from expression pattern
18413982 RGD
involved in response to aldosterone IEP
IEP: Inferred from expression pattern
29713904 RGD
involved in response to arsenic-containing substance IEP
IEP: Inferred from expression pattern
17487067 RGD
involved in response to corticosterone IEP
IEP: Inferred from expression pattern
17460069 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
11809910 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
18082050 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
17487067 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
17460069 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18230104 RGD
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
24828139 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdkn1a Protein Structure

CDI

CDI: pfam02234 (19 - 64)

  • 0
  • 100
  • 164 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase inhibitor 1

  • cyclin-dependent kinase inhibitor 1A (P21)

  • cyclin-dependent kinase inhibitor 1A (p21, Cip1)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10587 BIX-01294 98.44% Unkown
HY-161138 WK369 99.89% Unkown
HY-108239 BIX-01294 trihydrochloride 99.68% Unkown
HY-162384 EPIC-0628 Inhibitor 98.66% Unkown
HY-161024 AC1Q3QWB Inhibitor 99.76% Unkown
HY-161989 DZ-837 Degrader 96.04% Unkown
HY-180183 DLG-41 Inhibitor 98.06% Unkown
HY-148408 SIRT2-IN-11 Inhibitor 99.94% Unkown
HY-RS02410 CDKN1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16696 Cdkn1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-123994 Tenovin-D3 hydrochloride Inhibitor / Unkown
HY-180886 ZD-1-186 Inhibitor / Unkown
HY-182744 LLQ-45 Agonist / Unkown
HY-184244 CAS-010 Inhibitor / Unkown
HY-184495 PROTAC YTHDC1 Degrader-1 Inducer / Unkown
HY-N7175 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol Inducer / Unkown
HY-RS02411 Cdkn1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdkn1a NCBI NCBI:1026