2. Gene
  3. Adam17 - a disintegrin and metallopeptidase domain 17 Gene

Adam17 - a disintegrin and metallopeptidase domain 17 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Tace; CD156b

Gene ID: 11491 | Gene type: protein coding

About Adam17

Chromosome 12: 21,373,510-21,423,633 reverse strand.GRCm39:CM001005.3

This gene has 10 transcripts (splice variants), 283 orthologues, 35 paralogues and is associated with 123 phenotypes. Ubiquitous expression in placenta adult (RPKM 12.8), CNS E11.5 (RPKM 9.9) and 28 other tissues.

Summary

This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature Enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero or fail to survive beyond one week of age. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]

Adam17 Products(3)

mRNA Protein Name
NM_001277266.1 NP_001264195.1 disintegrin and metalloproteinase domain-containing protein 17 isoform 2 precursor
NM_009615.6 NP_033745.4 disintegrin and metalloproteinase domain-containing protein 17 isoform 1 preproprotein
NM_001291871.1 NP_001278800.1 disintegrin and metalloproteinase domain-containing protein 17 isoform 4

Adam17 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: cl03265 (49 - 166)

ZnMc_TACE_like

ZnMc_TACE_like: cd04270 (222 - 476)

DISIN

DISIN: smart00050 (483 - 558)

ADAM17_MPD

ADAM17_MPD: pfam16698 (580 - 641)

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  • 827 a.a.
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 17

TNF-alpha convertase

TNF-alpha converting enzyme

Recombinant Adam17 Proteins

Cat. No. Product Name Accession Purity
HY-P78717 ADAM17/TACE Protein, Mouse (HEK293, His) Q9Z0F8 (P18-D563) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-10293 Aderbasib Inhibitor 98.09% Phase 2
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-115670 GW280264X Inhibitor 98.28% Unkown
HY-110397 KP-457 Inhibitor 99.18% Unkown
HY-120852 JG26 Inhibitor 98.01% Unkown
HY-P3722A Mca-PLAQAV-Dpa-RSSSR-NH2 TFA 99.21% Unkown
HY-P3722 Mca-PLAQAV-Dpa-RSSSR-NH2 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adam17 NCBI NCBI:6868
Rattus norvegicus Adam17 NCBI NCBI:57027