Aga - aspartylglucosaminidase Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11593

Summary

This gene encodes an amidase enzyme that participates in the breakdown of glycoproteins in the cell. The encoded protein undergoes proteolytic processing to generate a mature enzyme. Mice lacking the encoded protein exhibit accumulation of aspartylglucosamine along with lysosomal vacuolization, axonal swelling in the gracile nucleus and impaired neuromotor coordination. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]

Aga Products (2)

mRNA Protein Name
NM_001005847.2 NP_001005847.1 N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform 1 preproprotein
NM_001205054.1 NP_001191983.1 N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform 2 precursor
Protein Preferred Names Protein Names

N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase

  • N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase

  • glycosylasparaginase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-132609 Patisiran sodium 99.09% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-132596 Tivanisiran Inhibitor 97.48% Phase 3
HY-147412 Ultevursen Modulator 94.24% Phase 3

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150724 ODN 1018 Agonist 99.28% Unkown
HY-108753 Eteplirsen Inducer 98.50% Unkown
HY-143230 Custirsen Inducer 96.12% Unkown
HY-P1851A AGA-(C8R) HNG17, humanin derivative TFA 99.22% Unkown
HY-118528A TP0427736 hydrochloride Inhibitor 99.91% Unkown
HY-145726 ISIS 104838 Inhibitor 91.02% Unkown
HY-161618 MJ04 Inhibitor 98.08% Unkown
HY-170448 PROTAC AR Degrader-9 Degrader / Unkown
HY-170450 AR ligand-38 Ligand / Unkown
HY-P1851 AGA-(C8R) HNG17, humanin derivative / Unkown
HY-RS00436 AGA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-175719 SRD5A1-IN-2 Inhibitor / Unkown
HY-RS17521 Aga Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23977 Aga Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992113 Evabosmig Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aga NCBI NCBI:175