Wnk1 - WNK lysine deficient protein kinase 1 Gene

Also Known as Hsn2; Prkwnk1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 116477

Summary

Enables several functions, including ATP binding activity; magnesium ion binding activity; and Potassium Channel Inhibitor activity. Involved in several processes, including cellular response to calcium ion; negative regulation of sodium ion transport; and protein autophosphorylation. Located in cytosol and membrane. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2A; hereditary sensory neuropathy; hypertension; and pseudohypoaldosteronism. Orthologous to human WNK1 (WNK lysine deficient protein kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Wnk1 Products (3)

mRNA	Protein	Name
NM_001002823.2	NP_001002823.2	serine/threonine-protein kinase WNK1 isoform 1
NM_001199095.1	NP_001186024.1	serine/threonine-protein kinase WNK1 isoform 2
NM_053794.2	NP_446246.2	serine/threonine-protein kinase WNK1 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	10828064	RGD
enables magnesium ion binding	IMP IMP: Inferred from mutant phenotype	10828064	RGD
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	36318922	RGD
enables potassium channel inhibitor activity	IDA IDA: Inferred from direct assay	16775035	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15350218	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16083423	RGD
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10828064	RGD
enables protein serine/threonine kinase inhibitor activity	IDA IDA: Inferred from direct assay	15081430	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cell volume homeostasis	IDA IDA: Inferred from direct assay	36318922	RGD
involved in cellular hyperosmotic response	IDA IDA: Inferred from direct assay	36318922	RGD
involved in cellular response to calcium ion	IDA IDA: Inferred from direct assay	24803536	RGD
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	10828064	RGD
involved in modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	26126716	RGD
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	26126716	RGD
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	26126716	RGD
involved in negative regulation of kinase activity	IDA IDA: Inferred from direct assay	15081430	RGD
involved in negative regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	17673510	RGD
involved in negative regulation of sodium ion transport	IDA IDA: Inferred from direct assay	16204408	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	10828064	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10828064	RGD
involved in regulation of sodium ion transport	IDA IDA: Inferred from direct assay	16204408	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	EXP EXP: Inferred from Experiment	26126716	RGD
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	26126716	RGD
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	26126716	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	10828064	RGD
located in cytosol	IDA IDA: Inferred from direct assay	25515571	RGD
is active in intracellular non-membrane-bounded organelle	IDA IDA: Inferred from direct assay	36318922	RGD
located in membrane	IDA IDA: Inferred from direct assay	25515571	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
serine/threonine-protein kinase WNK1	protein kinase with no lysine 1

Wnk1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Wnk1	Q9JIH7	Syt2	Rattus norvegicus	P29101	Anti Tag CoIP	15350218
Intra	Wnk1	Q9JIH7	Syt2	Rattus norvegicus	P29101	Biochemical	15350218
Intra	Wnk1	Q9JIH7	Syt2	Rattus norvegicus	P29101	Pull Down	15350218

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100626	WNK463	Inhibitor	99.75%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wnk1	NCBI	NCBI:65125