Syt2 - synaptotagmin 2 Gene

Also Known as SYNII; RATSYNII

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24805

Summary

Enables calcium-dependent phospholipid binding activity and syntaxin binding activity. Predicted to be involved in several processes, including positive regulation of dendrite extension; regulation of secretion by cell; and synaptic vesicle cycle. Located in terminal bouton. Is integral component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome and congenital myasthenic syndrome 7. Orthologous to human SYT2 (synaptotagmin 2). [provided by Alliance of Genome Resources, Apr 2022]

Syt2 Products (1)

mRNA Protein Name
NM_012665.2 NP_036797.2 synaptotagmin-2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent phospholipid binding IDA
IDA: Inferred from direct assay
7791877 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9303303 RGD
enables syntaxin binding IDA
IDA: Inferred from direct assay
7791877 RGD
Cellular Component GO Annotation Evidence References Source
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
9867811 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

synaptotagmin-2

  • synaptotagmin II

  • sytII

Syt2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Syt2 P29101 WNK1 Homo sapiens Q9H4A3
Anti Tag CoIP
15350218
Intra
Syt2 P29101 Wnk1 Rattus norvegicus Q9JIH7
Biochemical
15350218
Intra
Syt2 P29101 Wnk1 Rattus norvegicus Q9JIH7
Anti Tag CoIP
15350218
Intra
Syt2 P29101 Wnk1 Rattus norvegicus Q9JIH7
Y2H
15350218
Cross
Syt2 P29101 botB Clostridium botulinum P10844
Pull Down
22265973
Cross
Syt2 P29101 botB Clostridium botulinum P10844
Pull Down
16545378
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14114 SYT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Syt2 NCBI NCBI:127833