Dusp6 - dual specificity phosphatase 6 Gene

Also Known as Mkp3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116663

Summary

Enables protein tyrosine/serine/threonine Phosphatase activity. Involved in several processes, including negative regulation of ERK1 and ERK2 cascade; positive regulation of cell death; and response to growth factor. Located in cytosol. Biomarker of brain ischemia; pancreatitis; and visual epilepsy. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Orthologous to human DUSP6 (dual specificity Phosphatase 6). [provided by Alliance of Genome Resources, Apr 2022]

Dusp6 Products (1)

mRNA Protein Name
NM_053883.3 NP_446335.1 dual specificity protein phosphatase 6

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein tyrosine/serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
8631996 RGD
Biological Process GO Annotation Evidence References Source
involved in cell differentiation IEP
IEP: Inferred from expression pattern
8631996 RGD
involved in negative regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
8626780 RGD
involved in response to growth factor IEP
IEP: Inferred from expression pattern
9559664 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
17881770 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11701771 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dual specificity protein phosphatase 6

  • MAP kinase phosphatase 3

  • MKP-3

  • mitogen-activated protein kinase phosphatase 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-115502 BCI Inhibitor 99.73% Unkown
HY-115502A BCI hydrochloride Inhibitor 99.93% Unkown
HY-168012 Pan-RAS-IN-6 Inhibitor / Unkown
HY-RS04067 DUSP6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-126390 (E/Z)-BCI 99.38% Unkown
HY-181889 KRAS G12C-IN-75 Inhibitor / Unkown
HY-RS17007 Dusp6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23450 Dusp6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dusp6 NCBI NCBI:1848