(S)-SHP844-NHS
(S)-SHP844-NHS is a covalent allosteric, selective SHP2 inhibitor with an IC50 of 15.0 nM and a Ki of 0.037 μM. (S)-SHP844-NHS inhibits DUSP6 mRNA. (S)-SHP844-NHS can be used for research on lung cancer.
For research use only. We do not sell to patients.
- Formula: C33H27ClN6O8
- Molecular Weight:671.06
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
SHP2 15.0 nM (IC50) |
In Vitro
(S)-SHP844-NHS (Compound 26) inhibits SHP2 in the DiFMUP biochemical assay with an IC50 of 15 nM and acts by acylating K274[1].
(S)-SHP844-NHS covalently inactivates SHP2 with KI = 0.037 µM and kinact/KI = 1 min−1 µM−1[1].
(S)-SHP844-NHS (1 µM) is >60-fold selective for SHP2 over SHP1 and PTP1B in DiFMUP assays[1].
(S)-SHP844-NHS (1 µM) inhibits DUSP6 mRNA in H1650 cells by 76.5% and does not affect A375 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 671.06
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Formula C33H27ClN6O8
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SMILES
OC1=C(OC)C=CC=C1C2=NN=C(N3CC4=CC=C(C(N5[C@H](C(ON6C(CCC6=O)=O)=O)CCC5)=O)C=C4Cl)N2C7=C(C=CC=C7)C3=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S)-SHP844-NHS Related Classifications
HY-189844 Related Classifications
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