2. Gene
  3. Aldh2 - aldehyde dehydrogenase 2, mitochondrial Gene

Aldh2 - aldehyde dehydrogenase 2, mitochondrial Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ahd5; ALDHI; Ahd-5; AHD-M1; ALDH-E2

Gene ID: 11669 | Gene type: protein coding

About Aldh2

Chromosome 5: 121,704,090-121,731,887 reverse strand.GRCm39:CM000998.3

This gene has 7 transcripts (splice variants), 224 orthologues, 19 paralogues and is associated with 57 phenotypes. Broad expression in adrenal adult (RPKM 574.9), liver adult (RPKM 432.) and 18 other tissues.

Summary

Predicted to enable NADH binding activity; aldehyde dehydrogenase (NAD+) activity; and identical protein binding activity. Predicted to be involved in several processes, including behavioral response to ethanol; cellular detoxification of aldehyde; and intrinsic apoptotic signaling pathway in response to oxidative stress. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); diabetic neuropathy; and liver disease (multiple). Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member). [provided by Alliance of Genome Resources, Apr 2022]

Aldh2 Products(2)

mRNA Protein Name
NM_001308450.1 NP_001295379.1 aldehyde dehydrogenase, mitochondrial isoform 2 precursor
NM_009656.4 NP_033786.1 aldehyde dehydrogenase, mitochondrial isoform 1 precursor

Aldh2 Protein Structure

ALDH_F1AB_F2_RALDH1

ALDH_F1AB_F2_RALDH1: cd07141 (32 - 512)

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  • 519 a.a.
Protein Preferred Names Protein Names

aldehyde dehydrogenase, mitochondrial

ALDH class 2

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0364A Dyclonine hydrochloride Inhibitor 99.86% Unkown
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-113466 4-Hydroxynonenal Inhibitor ≥99.0% Unkown
HY-18936 Alda-1 Agonist 99.99% Unkown
HY-146683 KS106 Inhibitor 99.31% Unkown
HY-76006 3-Hydroxybenzaldehyde 99.85% Unkown
HY-126241 RV01 Inhibitor 98.0% Unkown
HY-113466S 4-Hydroxynonenal-d3 Inhibitor ≥99.0% Unkown
HY-148617 ALDH2 modulator 1 Modulator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aldh2 NCBI NCBI:217