ARAP2 - ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 Gene

Also Known as PARX; CENTD1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 116984

About ARAP2

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:36,005,404-36,244,784 (from NCBI)

This gene has 9 transcripts (splice variants), 126 orthologues and 28 paralogues. Broad expression in thyroid (RPKM 5.9), brain (RPKM 5.8) and 22 other tissues.

Summary

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]

ARAP2 Products (1)

mRNA Protein Name
NM_015230.4 NP_056045.2 arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: Inferred from direct assay
11804589 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARAP2 Protein Structure

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (10 - 65)

PH

PH: PH domain (484 - 573)

PH

PH: PH domain (591 - 678)

ArfGap

ArfGap: Putative GTPase activating protein for Arf (687 - 801)

PH

PH: PH domain (910 - 1000)

RhoGAP

RhoGAP: RhoGAP domain (1129 - 1278)

RA

RA: Ras association (RalGDS/AF-6) domain (1329 - 1413)

PH

PH: PH domain (1436 - 1533)

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  • 1704 a.a.
Protein Preferred Names Protein Names

arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

  • Arf and Rho GAP adapter protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00888 ARAP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ARAP2 VGNC VGNC:59863
Mus musculus ARAP2 MGD MGI:2684416
Macaca mulatta ARAP2 VGNC VGNC:69843
Rattus norvegicus ARAP2 RGD RGD:1306452
Canis familiaris ARAP2 VGNC VGNC:38026
Bos taurus ARAP2 VGNC VGNC:26055