Ccr3 - C-C motif chemokine receptor 3 Gene

Also Known as Cmkbr3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117027

About Ccr3

Primary_assembly 8: 123,616,236-123,634,990 forward strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 142 orthologues, 24 paralogues and is associated with 40 phenotypes. Biased expression in Spleen (RPKM 24.1) and Uterus (RPKM 12.4).

Summary

Predicted to enable C-C chemokine binding activity and C-C Chemokine Receptor activity. Involved in ERK1 and ERK2 cascade; angioblast cell migration; and leukocyte chemotaxis. Located in endosome; extracellular space; and plasma membrane. Used to study asthma and myocardial infarction. Biomarker of rhinitis. Human ortholog(s) of this gene implicated in asthma; ovary epithelial cancer; and rhinitis. Orthologous to human CCR3 (C-C motif Chemokine Receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Ccr3 Products (1)

mRNA Protein Name
NM_053958.2 NP_446410.1 C-C chemokine receptor type 3

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
12413953 RGD
involved in angioblast cell migration IMP
IMP: Inferred from mutant phenotype
18954648 RGD
involved in eosinophil chemotaxis IMP
IMP: Inferred from mutant phenotype
16978084 RGD
involved in mast cell chemotaxis IMP
IMP: Inferred from mutant phenotype
12413953 RGD
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
12004163 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
12004163 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ccr3 Protein Structure

7tmA_CCR3

7tmA_CCR3: cd15185 (38 - 315)

7tmA_CCR3

7tmA_CCR3: cd15185 (38 - 65)

7tmA_CCR3

7tmA_CCR3: cd15185 (72 - 97)

7tmA_CCR3

7tmA_CCR3: cd15185 (109 - 139)

7tmA_CCR3

7tmA_CCR3: cd15185 (151 - 173)

7tmA_CCR3

7tmA_CCR3: cd15185 (199 - 228)

7tmA_CCR3

7tmA_CCR3: cd15185 (235 - 265)

7tmA_CCR3

7tmA_CCR3: cd15185 (283 - 308)

  • 0
  • 100
  • 200
  • 300
  • 359 a.a.
Protein Preferred Names Protein Names

C-C chemokine receptor type 3

  • C-C CKR-3

  • CC-CKR-3

  • CCR-3

  • CKR3

  • chemokine (C-C motif) receptor 3

  • chemokine (C-C) receptor 3

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-136788 ALK4290 Inhibitor 99.79% Phase 2

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103363 SB-328437 Antagonist 99.58% Unkown
HY-103360 J-113863 Antagonist ≥99.0% Unkown
HY-107051 GW 766994 Antagonist 98.73% Unkown
HY-103361 SB297006 Antagonist 99.86% Unkown
HY-P3982 CKLF1-C19 Chemical 99.11% Unkown
HY-U00331 CCR3 antagonist 1 Antagonist 99.90% Unkown
HY-182736 YM-344484 Antagonist / Unkown
HY-N10397 Maceneolignan H Antagonist / Unkown
HY-160998 YM-344031 Antagonist / Unkown
HY-182735 BMS-570520 Antagonist / Unkown
HY-182439 AZD3778 Inhibitor / Unkown
HY-120629 BMS-639623 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccr3 NCBI NCBI:1232