HMGA1 - Hmga1 high mobility group AT-hook 1 Gene

Predicted to enable several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and catalytic activity, acting on DNA. Predicted to be involved in several processes, including oncogene-induced cell senescence; positive regulation of cellular senescence; and regulation of transcription, DNA-templated. Predicted to act upstream of or within spermatogenesis. Predicted to be located in senescence-associated heterochromatin focus. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human HMGA1 (high mobility group AT-hook 1). [provided by Alliance of Genome Resources, Apr 2022]