DACH2 - dachshund family transcription factor 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 117154

About DACH2

Cytogenetic location: Xq21.2 Genomic coordinates (GRCh38): X:86,148,451-86,832,602 (from NCBI)

This gene has 7 transcripts (splice variants), 257 orthologues and 1 paralogue. Biased expression in brain (RPKM 3.6) and kidney (RPKM 0.3).

Summary

This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

DACH2 Products (3)

mRNA Protein Name
NM_001139514.1 NP_001132986.1 dachshund homolog 2 isoform b
NM_001139515.1 NP_001132987.1 dachshund homolog 2 isoform c
NM_053281.3 NP_444511.1 dachshund homolog 2 isoform a

DACH2 Protein Structure

Ski_Sno

Ski_Sno: SKI/SNO/DAC family (38 - 162)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 599 a.a.
Protein Preferred Names Protein Names

dachshund homolog 2

Related Diseases

Diseases Alias
Enterobiasis

  • Oxyuriasis

  • Pinworm Infection

  • Enterobius Vermicularis Infection

  • Threadworm Infection

  • Oxyuris Vermicularis Infection

  • Enterobiosis

  • Pinworm

  • Pinworm Disease

  • Seatworm Infection

  • Enterobiasis Threadworm

  • Pinworm Infestation

  • Seatworm
Miles-Carpenter Syndrome

  • X-Linked Intellectual Disability, Miles-Carpenter Type

  • Mcs

  • Mental Retardation, X-Linked, Syndromic 4

  • Mental Retardation, X-Linked, With Congenital Contractures And Low Fingertip Arches

  • Mrxs4

  • Miles-Carpenter X-Linked Mental Retardation Syndrome
Mullerian Aplasia And Hyperandrogenism

  • Mullerian Duct Failure And Hyperandrogenism

  • Wnt4 Deficiency

  • Müllerian Aplasia And Hyperandrogenism

  • Biason-Lauber Syndrome

  • Mayer-Rokitansky-Küster-Hauser-Biason-Lauber Syndrome

  • Mayer-Rokitansky-Küster-Hauser-Like Syndrome

  • Müllerian Duct Failure

  • Wnt4 Müllerian Aplasia

  • Wnt4 Müllerian Aplasia And Ovarian Dysfunction

  • MULLAPL

  • Wnt4 Mullerian Aplasia And Ovarian Dysfunction
Deafness, X-Linked 7

  • X-Linked External Auditory Canal Atresia-Dilated Internal Auditory Canal-Facial Dysmorphism Syndrome

  • DFNX7

  • X-Linked Deafness 7

  • Deafness, X-Linked, 7
Premature Menopause

  • Primary Ovarian Insufficiency

  • Premature Ovarian Failure

  • Hypergonadotropic Hypogonadism

  • Premature Ovarian Insufficiency

  • Menopause - Premature

  • Menopause Praecox

  • Menopause Premature

  • Menopause, Premature

  • Female Hypergonadotropic Hypogonadism

  • Hypergonadotrophic Ovarian Failure

  • Primary Female Hypogonadism

  • Pof - [Premature Ovarian Failure]

  • Ovarian Failure

  • Ovarian Secretion Suppression

  • Ovary Hyposecretion

  • Ovary Secretion Deficiency

  • Premature Menopause Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS03514 DACH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DACH2 RGD RGD:1561687
Mus musculus DACH2 MGD MGI:1890446
Canis familiaris DACH2 VGNC VGNC:54131
Macaca mulatta DACH2 VGNC VGNC:71635
Bos taurus DACH2 VGNC VGNC:106705
Others DACH2 NCBI