Areg - amphiregulin Gene

Also Known as AR; Mcub; Sdgf

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11839

Summary

This gene encodes a member of the epidermal growth factor (EGF) family and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and has been shown to play a role in immunity, inflammation, tissue repair, and lung and mammary gland development. Homozygous knockout mice for this gene exhibit impaired immune system regulation in the skin and gene expression changes characteristic of chronic liver damage. [provided by RefSeq, Aug 2015]

Areg Products (1)

mRNA Protein Name
NM_009704.4 NP_033834.1 amphiregulin preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables receptor ligand activity IGI
IGI: Inferred from genetic interaction
23086930 MGI
enables transmembrane receptor protein tyrosine kinase activator activity IGI
IGI: Inferred from genetic interaction
23086930 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis IMP
IMP: Inferred from mutant phenotype
17369357 MGI
involved in epidermal growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
23086930 MGI
acts upstream of or within epithelial cell proliferation involved in mammary gland duct elongation IMP
IMP: Inferred from mutant phenotype
17369357 MGI
acts upstream of or within mammary gland alveolus development IGI
IGI: Inferred from genetic interaction
10331984 MGI
acts upstream of or within mammary gland branching involved in thelarche IMP
IMP: Inferred from mutant phenotype
10331984 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
8702723 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
8702723 MGI
acts upstream of or within response to estradiol IDA
IDA: Inferred from direct assay
17369357 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
8588926 MGI
is active in extracellular space IDA
IDA: Inferred from direct assay
23086930 MGI
is active in extracellular space IGI
IGI: Inferred from genetic interaction
30770250 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
8588926 MGI
located in nucleus IDA
IDA: Inferred from direct assay
8588926 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

amphiregulin

  • schwannoma-derived growth factor

Recombinant Areg Proteins

Cat. No. Product Name Accession Purity
HY-P77868 Amphiregulin Protein, Mouse (HEK293, Fc) P31955 (V100-A248) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00892 AREG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174779 Human AREG mRNA / Unkown
HY-RS17019 Areg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23462 Areg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991748 Anti-Human/Mouse Amphiregulin Antibody (AR37) Inhibitor 99.544% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Areg NCBI NCBI:374