AREG - amphiregulin Gene
Also Known as AR; SDGF; AREGB; CRDGF
Species: Homo sapiens
About AREG
This gene has 3 transcripts (splice variants), 122 orthologues and 5 paralogues. Biased expression in placenta (RPKM 177.3), bone marrow (RPKM 37.7) and 5 other tissues.
Summary
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with Other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014]
AREG Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001657.4 | NP_001648.1 | amphiregulin preproprotein |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
19740107 | GOA |
| enables receptor ligand activity |
IDA
IDA: Inferred from direct assay
|
8702723 | GOA |
| enables transmembrane receptor protein tyrosine kinase activator activity |
IDA
IDA: Inferred from direct assay
|
8702723 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in ERBB2-EGFR signaling pathway |
IDA
IDA: Inferred from direct assay
|
8702723 | GOA |
| involved in G protein-coupled receptor signaling pathway |
IDA
IDA: Inferred from direct assay
|
12743035 | GOA |
| involved in epidermal growth factor receptor signaling pathway |
IDA
IDA: Inferred from direct assay
|
12743035 | GOA |
| involved in positive regulation of cell population proliferation |
IMP
IMP: Inferred from mutant phenotype
|
12743035 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cell surface |
IDA
IDA: Inferred from direct assay
|
12743035 | GOA |
| is active in extracellular space |
IDA
IDA: Inferred from direct assay
|
8702723 | GOA |
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
12743035 | GOA |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
amphiregulin |
|
AREG Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
AREG | P15514 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
AREG | P15514 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
AREG | P15514 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
AREG | P15514 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
AREG | P15514 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 |
Recombinant AREG Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7002 | Amphiregulin Protein, Human (HEK293) | P15514 (S101-K198) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70578 | Amphiregulin Protein, Human | P15514 (S101-K198) | ≥ 95%, as determined by reducing SDS-PAGE. |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Ovarian Cystadenoma |
|
|
| Lymphangioma |
|
|
| Psoriasis |
|
|
| Mucoepidermoid Carcinoma |
|
|
| Colorectal Cancer |
|
|
| Breast Cancer |
|
|
| Gastritis |
|
|
| Keratoacanthoma |
|
|
| Lung Cancer |
|
|
| Bladder Cancer |
|
|
| Squamous Blepharitis |
|
|
| Pyometritis |
|
|
| Colon Adenocarcinoma |
|
|
| Tylosis With Esophageal Cancer |
|
|
| Cystadenocarcinoma |
|
|
| Vallecula Cancer |
|
|
| Pancreatic Cancer |
|
|
| Endometrial Cancer |
|
|
| Gastric Cancer |
|
|
| Ovarian Cancer |
|
|
| Pulmonary Disease, Chronic Obstructive |
|
|
| Asthma |
|
|
| Inflammatory Bowel Disease |
|
|
| Bronchiectasis 2 |
|
|
| Silo Filler'S Disease |
|
|
| Prostate Cancer |
|
|
| Mixed Cell Adenoma |
|
|
| Hepatocellular Carcinoma |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Capillary Lymphangioma |
|
|
| Skin Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | AREG | MGD | MGI:88068 |
| Felis catus | AREG | VGNC | VGNC:68018 |
| Canis familiaris | AREG | VGNC | VGNC:54919 |
| Bos taurus | AREG | VGNC | VGNC:50208 |
| Macaca mulatta | AREG | VGNC | VGNC:70000 |
| Rattus norvegicus | AREG | RGD | RGD:2149 |
| Others | AREG | NCBI |