Atf3 - activating transcription factor 3 Gene

Also Known as LRG-21

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11910

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of ERK1 and ERK2 cascade; and regulation of gene expression. Acts upstream of or within gluconeogenesis; negative regulation of transcription, DNA-templated; and skeletal muscle cell differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and limb long bone. Orthologous to human ATF3 (activating transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Atf3 Products (1)

mRNA Protein Name
NM_007498.3 NP_031524.2 cyclic AMP-dependent transcription factor ATF-3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
11916968 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
16644691 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16644691 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to amino acid starvation IMP
IMP: Inferred from mutant phenotype
14729979 MGI
involved in endoplasmic reticulum unfolded protein response IMP
IMP: Inferred from mutant phenotype
14729979 MGI
acts upstream of or within gluconeogenesis IDA
IDA: Inferred from direct assay
11916968 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11916968 MGI
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
22053207 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16644691 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
14729979 MGI
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
24939851 MGI
acts upstream of or within skeletal muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
22147266 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
14729979 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclic AMP-dependent transcription factor ATF-3

  • cAMP-dependent transcription factor ATF-3

  • transcription factor LRG-21

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-151923 ATF3 inducer 1 Inhibitor 99.61% Unkown
HY-153347 JY-2 99.75% Unkown
HY-W011927 4,4'-Sulfonyldiphenol 99.81% Unkown
HY-12756 E6446 98.78% Unkown
HY-12756A E6446 dihydrochloride 99.29% Unkown
HY-175032 ATF3-IN-1 96.30% Unkown
HY-N0660 Jujuboside B 99.92% Unkown
HY-W011927S 4,4'-Sulfonyldiphenol-d8 99.21% Unkown
HY-RS01129 ATF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-162384 EPIC-0628 Inhibitor 98.66% Unkown
HY-163319 NCA029 98.24% Unkown
HY-178154 FB231 99.45% Unkown
HY-155158 Anticancer agent 147 Inducer / Unkown
HY-181982 HJ03 / Unkown
HY-N0660R Jujuboside B (Standard) / Unkown
HY-RS16909 Atf3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23351 Atf3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atf3 NCBI NCBI:467