Bmpr2 - bone morphogenetic protein receptor, type II (serine/threonine kinase) Gene

Mus musculus

Also known as BMP-2; BRK-3; BMPR-2; BMPRII; BMPR-II; Gm20272; 2610024H22Rik

Gene ID: 12168 | Gene type: protein coding

About Bmpr2

Chromosome 1: 59,802,559-59,918,173 forward strand.GRCm39:CM000994.3

This gene has 3 transcripts (splice variants), 265 orthologues, 11 paralogues and is associated with 44 phenotypes. Broad expression in lung adult (RPKM 22.1), frontal lobe adult (RPKM 8.3) and 19 other tissues.

Summary

This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type II receptor that binds extracellular BMPs and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important during embryonic development. Mutations in this gene can cause pulmonary hypertension. [provided by RefSeq, Mar 2013]

Bmpr2 Products(1)

mRNA	Protein	Name
NM_007561.4	NP_031587.1	bone morphogenetic protein receptor type-2 precursor

Bmpr2 Protein Structure

Activin_recp

STKc_BMPR2_AMHR2

0
200
400
600
800
1038 a.a.

Protein Preferred Names

Protein Names

bone morphogenetic protein receptor type-2

BMP type II receptor	BMP type-2 receptor
bone morphogenic protein receptor, type II (serine/threonine kinase)

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15897	LDN-212854	Inhibitor	99.70%	Unkown
HY-154970A	BMPR2-IN-1 TFA	Inhibitor	99.40%	Unkown
HY-154970	BMPR2-IN-1	Inhibitor	/	Unkown
HY-RS01552	BMPR2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS01553	Bmpr2 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS01554	Bmpr2 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bmpr2	NCBI	NCBI:659

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