Calm2 - calmodulin 2 Gene

Also Known as Cam2; CamC; 1500001E21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12314

Summary

Enables calcium-dependent protein binding activity. Involved in negative regulation of calcium ion export across plasma membrane and negative regulation of calcium ion transmembrane transporter activity. Acts upstream of or within G2/M transition of mitotic cell cycle and regulation of calcium-mediated signaling. Located in membrane; myelin sheath; and vesicle. Part of voltage-gated Potassium Channel complex. Is expressed in several structures, including alimentary system; metanephros; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in long QT syndrome 15. Orthologous to human CALM2 (Calmodulin 2). [provided by Alliance of Genome Resources, Apr 2022]

Calm2 Products (2)

mRNA Protein Name
NM_001355703.1 NP_001342632.1 calmodulin-2 isoform 2
NM_007589.5 NP_031615.1 calmodulin-2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
33199372 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12051765 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G2/M transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
2469574 MGI
involved in negative regulation of calcium ion export across plasma membrane IDA
IDA: Inferred from direct assay
33199372 MGI
involved in negative regulation of calcium ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
33199372 MGI
involved in presynaptic endocytosis IDA
IDA: Inferred from direct assay
31628181 MGI
involved in presynaptic endocytosis IMP
IMP: Inferred from mutant phenotype
31628181 MGI
acts upstream of or within regulation of calcium-mediated signaling IGI
IGI: Inferred from genetic interaction
33199372 MGI
Cellular Component GO Annotation Evidence References Source
is active in calyx of Held IDA
IDA: Inferred from direct assay
31628181 MGI
is active in calyx of Held IMP
IMP: Inferred from mutant phenotype
31628181 MGI
located in membrane IDA
IDA: Inferred from direct assay
33199372 MGI
located in myelin sheath IDA
IDA: Inferred from direct assay
19855925 MGI
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
31628181 MGI
is active in presynaptic cytosol IMP
IMP: Inferred from mutant phenotype
31628181 MGI
located in vesicle IDA
IDA: Inferred from direct assay
33199372 MGI
part of voltage-gated potassium channel complex IGI
IGI: Inferred from genetic interaction
12223552 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calmodulin-2

  • caM

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS26152 Calm2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Calm2 NCBI NCBI:805