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Cav3 - caveolin 3 Gene

Also Known as Cav-3; M-cav

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12391

Summary

This gene belongs to the caveolin family whose members encode the major protein components of caveolae, which are invaginations of plasma membrane. The encoded protein is muscle-specific and forms homooligomers in muscle cells. The protein binds and regulates phosphofructokinase M and neuronal nitric oxide synthase. It also associates with Dystrophin in muscle cells. Mutations in this gene are associated with muscular dystrophy. [provided by RefSeq, Apr 2013]

Cav3 Products (1)

mRNA	Protein	Name
NM_007617.3	NP_031643.1	caveolin-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables alpha-tubulin binding	IDA IDA: Inferred from direct assay	14517320	MGI
enables connexin binding	IPI IPI: Inferred from physical interaction	19544087	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8663016	MGI
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	19238754	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of MAPK cascade	IMP IMP: Inferred from mutant phenotype	12138167	MGI
acts upstream of or within actin filament organization	IMP IMP: Inferred from mutant phenotype	14517320	MGI
acts upstream of calcium ion transport	IMP IMP: Inferred from mutant phenotype	21084288	MGI
acts upstream of or within cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	19535499	MGI
acts upstream of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	18552160	MGI
acts upstream of or within caveola assembly	IMP IMP: Inferred from mutant phenotype	18054955	MGI
acts upstream of or within cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	15314230	MGI
acts upstream of or within cytoplasmic microtubule organization	IMP IMP: Inferred from mutant phenotype	14517320	MGI
involved in detection of muscle stretch	IMP IMP: Inferred from mutant phenotype	25257915	MGI
acts upstream of or within endocytosis	IMP IMP: Inferred from mutant phenotype	14600260	MGI
acts upstream of establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	21084288	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	14600260	MGI
acts upstream of or within glucose homeostasis	IMP IMP: Inferred from mutant phenotype	15314230	MGI
acts upstream of or within heart trabecula formation	IMP IMP: Inferred from mutant phenotype	19535499	MGI
acts upstream of or within membrane raft organization	IMP IMP: Inferred from mutant phenotype	11259414	MGI
acts upstream of or within myoblast fusion	IMP IMP: Inferred from mutant phenotype	14517320	MGI
acts upstream of myotube differentiation	IMP IMP: Inferred from mutant phenotype	14517320	MGI
acts upstream of or within myotube differentiation	IMP IMP: Inferred from mutant phenotype	21182936	MGI
acts upstream of or within negative regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	12138167	MGI
acts upstream of or within negative regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	21084288	MGI
acts upstream of or within negative regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	18552160	MGI
involved in negative regulation of membrane depolarization during cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	25257915	MGI
acts upstream of or within negative regulation of nitric-oxide synthase activity	IMP IMP: Inferred from mutant phenotype	11159934	MGI
acts upstream of or within negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	14600260	MGI
acts upstream of or within nucleus localization	IMP IMP: Inferred from mutant phenotype	19535499	MGI
acts upstream of or within plasma membrane organization	IMP IMP: Inferred from mutant phenotype	11115849	MGI
acts upstream of or within plasma membrane repair	IMP IMP: Inferred from mutant phenotype	19380584	MGI
acts upstream of or within positive regulation of myotube differentiation	IMP IMP: Inferred from mutant phenotype	14517320	MGI
acts upstream of or within protein localization	IGI IGI: Inferred from genetic interaction	15277200	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	11259414	MGI
acts upstream of or within protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	16455755	MGI
acts upstream of or within regulation of branching involved in mammary gland duct morphogenesis	IMP IMP: Inferred from mutant phenotype	19164602	MGI
acts upstream of or within regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	16648270	MGI
acts upstream of or within regulation of membrane potential	IGI IGI: Inferred from genetic interaction	15277200	MGI
acts upstream of or within regulation of p38MAPK cascade	IMP IMP: Inferred from mutant phenotype	21182936	MGI
acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	21182936	MGI
acts upstream of or within regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21182936	MGI
acts upstream of or within triglyceride metabolic process	IMP IMP: Inferred from mutant phenotype	15314230	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in T-tubule	IDA IDA: Inferred from direct assay	9008709	MGI
located in caveola	IDA IDA: Inferred from direct assay	9008709	MGI
located in membrane	IDA IDA: Inferred from direct assay	10835421	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	11259414	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	14600260	MGI
located in sarcolemma	IDA IDA: Inferred from direct assay	8663016	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
caveolin-3	M-caveolin

Cav3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Cav3	P51637	Adrb2	Mus musculus	P18762	Anti Bait CoIP	16648270
Intra	Cav3	P51637	Cacna1c	Mus musculus	Q01815	Anti Bait CoIP	16648270
Intra	Cav3	P51637	Cacna1g	Mus musculus	Q5SUG4	Anti Bait CoIP	21084288
Intra	Cav3	P51637	Cacna1h	Mus musculus	Q6PE92	EM	21084288
Intra	Cav3	P51637	Cacna1h	Mus musculus	Q6PE92	Pull Down	21084288
Intra	Cav3	P51637	Cacna1h	Mus musculus	Q6PE92	Anti Bait CoIP	21084288

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-B0166	L-Ascorbic acid	99.97%	Unkown
HY-B0166A	L-Ascorbic acid sodium salt	99.97%	Unkown
HY-B0166R	L-Ascorbic acid (Standard)	99.97%	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-B0166GL	L-Ascorbic acid (GMP Like)		99.88%	Phase 4
HY-B0166G	L-Ascorbic acid (GMP)		/	Phase 2
HY-115681	(2R/S)-6-PNG	Inhibitor	99.96%	Phase 1

Pre-clinical Phase

Bioactive Molecules (38)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111828	TTA-A2	Antagonist	99.33%	Unkown
HY-B0166S	L-Ascorbic acid-13C6		99.90%	Unkown
HY-103309	ML218	Inhibitor	99.49%	Unkown
HY-132184	5,6-Epoxyeicosatrienoic acid	Inhibitor	99.9%	Unkown
HY-120597	SAK3	Activator	99.80%	Unkown
HY-B0166S6	L-Ascorbic acid-d2		99.90%	Unkown
HY-B0166S1	L-Ascorbic acid-13C		99.90%	Unkown
HY-P1441A	Mambalgin 1 TFA	Inhibitor	95.72%	Unkown
HY-B0166S8	L-Ascorbic acid-13C6-1		99.37%	Unkown
HY-112499S1	Menaquinone-7-13C6		96.0%	Unkown
HY-147638	MONIRO-1	Inhibitor	99.18%	Unkown
HY-50707	(Rac)-TTA-P2	Control	98.69%	Unkown
HY-B0166S3	L-Ascorbic acid-13C-2		95.0%	Unkown
HY-103309A	ML218 hydrochloride	Inhibitor	/	Unkown
HY-10035A	(R)-TTA-P2	Control	99.95%	Unkown
HY-103309S	ML218-d9	Inhibitor	/	Unkown
HY-118030	RQ-00311651	Antagonist	/	Unkown
HY-126336	HM12	Inhibitor	/	Unkown
HY-129841	Niguldipine monohydrochloride	Inhibitor	/	Unkown
HY-132184S	5,6-Epoxyeicosatrienoic acid-d11		/	Unkown
HY-147639	Cav 2.2/3.2 blocker 1	Inhibitor	/	Unkown
HY-147708	T-Type calcium channel inhibitor 2	Inhibitor	/	Unkown
HY-151450	Cav 3.2 inhibitor 1	Inhibitor	/	Unkown
HY-151451	Cav 3.2 inhibitor 2	Inhibitor	/	Unkown
HY-151452	Cav 3.2 inhibitor 3	Inhibitor	/	Unkown
HY-154832	Cav 3.2 inhibitor 4	Inhibitor	/	Unkown
HY-177955	α-Obscurine derivative-1	Inhibitor	/	Unkown
HY-B0166E	L-Ascorbic acid magnesium		/	Unkown
HY-B0166S2	L-Ascorbic acid-13C-1		99.90%	Unkown
HY-B0166S4	L-Ascorbic acid-13C-3		/	Unkown
HY-B0166S5	L-Ascorbic acid-13C-4		/	Unkown
HY-P5793	GTx1-15	Inhibitor	/	Unkown
HY-P5869	Kurtoxin		/	Unkown
HY-RS01988	CAV3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-112499S	Menaquinone-7-d7		/	Unkown
HY-122201	NSC156529	Antagonist	/	Unkown
HY-156889	Cav 3.1 blocker 1	Antagonist	/	Unkown
HY-P3269	Calciseptine	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cav3	NCBI	NCBI:859