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Runx2 - runt related transcription factor 2 Gene

Also Known as Cbf; LS3; AML3; Osf2; Cbfa1; Cbfa-1; PEBP2aA; Pebp2a1; Pebpa2a; CBF-alpha-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12393

Summary

This gene encodes a member of the runt domain-containing family of transcription factors. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Sep 2015]

Runx2 Products (6)

mRNA	Protein	Name
NM_001145920.2	NP_001139392.1	runt-related transcription factor 2 isoform 2
NM_001146038.2	NP_001139510.1	runt-related transcription factor 2 isoform 1
NM_001271627.1	NP_001258556.1	runt-related transcription factor 2 isoform 1
NM_001271630.1	NP_001258559.1	runt-related transcription factor 2 isoform 3
NM_001271631.1	NP_001258560.1	runt-related transcription factor 2 isoform 4
NM_009820.5	NP_033950.2	runt-related transcription factor 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9182762	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12551949	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	31545469	MGI
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	12551949	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9182762	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IGI IGI: Inferred from genetic interaction	16751105	MGI
enables bHLH transcription factor binding	IPI IPI: Inferred from physical interaction	19144722	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	21930712	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	15537544	MGI
enables cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	31545469	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15150273	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	15030764	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	12551949	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	20843790	MGI
acts upstream of or within T cell differentiation	IDA IDA: Inferred from direct assay	7862157	MGI
acts upstream of bone mineralization	IDA IDA: Inferred from direct assay	21930712	MGI
acts upstream of bone mineralization	IMP IMP: Inferred from mutant phenotype	21930712	MGI
acts upstream of or within cell maturation	IGI IGI: Inferred from genetic interaction	15107406	MGI
acts upstream of or within cell maturation	IMP IMP: Inferred from mutant phenotype	15389629	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	16476422	MGI
involved in cell population proliferation	IGI IGI: Inferred from genetic interaction	22927960	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15668330	MGI
acts upstream of or within chondrocyte development	IMP IMP: Inferred from mutant phenotype	10213384	MGI
acts upstream of or within chondrocyte differentiation	IGI IGI: Inferred from genetic interaction	16476422	MGI
acts upstream of chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	10072783	MGI
acts upstream of or within chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	22916278	MGI
acts upstream of or within embryonic cranial skeleton morphogenesis	IGI IGI: Inferred from genetic interaction	15030764	MGI
acts upstream of or within embryonic forelimb morphogenesis	IMP IMP: Inferred from mutant phenotype	22916278	MGI
acts upstream of or within endochondral ossification	IMP IMP: Inferred from mutant phenotype	10072783	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15668330	MGI
acts upstream of positive effect gene expression	IDA IDA: Inferred from direct assay	21930712	MGI
involved in gene expression	IDA IDA: Inferred from direct assay	31281513	MGI
involved in ligamentous ossification	IGI IGI: Inferred from genetic interaction	22927960	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18804520	MGI
acts upstream of or within negative regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	15668330	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	15136142	MGI
acts upstream of or within osteoblast development	IGI IGI: Inferred from genetic interaction	18986983	MGI
involved in osteoblast differentiation	IDA IDA: Inferred from direct assay	21930712	MGI
acts upstream of or within osteoblast differentiation	IGI IGI: Inferred from genetic interaction	15565649	MGI
acts upstream of or within osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	15389629	MGI
acts upstream of or within osteoblast fate commitment	IGI IGI: Inferred from genetic interaction	15150273	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12551949	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	31545469	MGI
acts upstream of or within positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	16476422	MGI
acts upstream of or within positive regulation of chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	10072783	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	15668330	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	21324897	MGI
acts upstream of or within positive regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	15175325	MGI
acts upstream of or within positive regulation of osteoblast differentiation	IGI IGI: Inferred from genetic interaction	15150273	MGI
acts upstream of or within positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	15668330	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12434156	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9182762	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15150273	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	31336344	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20843790	MGI
acts upstream of or within regulation of fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15136142	MGI
acts upstream of or within regulation of gene expression	IDA IDA: Inferred from direct assay	24505141	MGI
acts upstream of or within regulation of odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	14688224	MGI
acts upstream of or within regulation of ossification	IMP IMP: Inferred from mutant phenotype	10213384	MGI
acts upstream of or within regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	21628588	MGI
involved in response to sodium phosphate	IDA IDA: Inferred from direct assay	23523568	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	14688224	MGI
acts upstream of or within skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	15030764	MGI
acts upstream of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	15668330	MGI
acts upstream of or within stem cell differentiation	IDA IDA: Inferred from direct assay	17693062	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	15668330	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	17352693	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	17182356	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12434156	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	16751105	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
runt-related transcription factor 2	AKV core binding factor PEA2-alpha A PEBP2 alpha A SL3-3 enhancer factor 1 alpha A subunit acute myeloid leukemia 3 protein core binding factor alpha 1 osteoblast-specific transcription factor 2 polyomavirus enhancer-binding protein 2 alpha A subun

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-Y0332B	Potassium dihydrogen phosphate, AR,99.5%	Activator	99.7%	Unkown
HY-P5832	BMP2-derived peptide	Activator	98.04%	Unkown
HY-107245	Segetalin B	Activator	99.9%	Unkown
HY-Y0332K	Potassium dihydrogen phosphate, for cell culture	Activator	/	Unkown
HY-W014410	Mucic acid	Activator	99.36%	Unkown
HY-W019901B	Anhydrous calcium sulfate (97%)	Activator	99.40%	Unkown
HY-W115785	Zinc borate	Activator	0	Unkown
HY-Y0332L	Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340	Activator	/	Unkown
HY-Y0332J	Potassium dihydrogen phosphate, United States Pharmacopeia (USP) Reference Standard	Activator	/	Unkown
HY-W014410R	Mucic acid (Standard)	Activator	/	Unkown
HY-Y0332G	Potassium dihydrogen phosphate, for molecular biology	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Runx2	NCBI	NCBI:860