Cckar - cholecystokinin A receptor Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12425

About Cckar

Chromosome 5: 53,855,118-53,865,047 reverse strand.GRCm39:CM000998.3

This gene has 3 transcripts (splice variants), 202 orthologues, 16 paralogues and is associated with 21 phenotypes. Biased expression in lung adult (RPKM 14.7), kidney adult (RPKM 12.1) and 4 other tissues.

Summary

Predicted to enable Cholecystokinin Receptor activity and peptide hormone binding activity. Acts upstream of or within axonogenesis; forebrain development; and neuron migration. Predicted to be located in several cellular components, including endosome; lysosome; and terminal bouton. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CCKAR (cholecystokinin A receptor). [provided by Alliance of Genome Resources, Apr 2022]

Cckar Products (2)

mRNA Protein Name
NM_009827.2 NP_033957.1 cholecystokinin receptor type A isoform 1
NM_001347354.1 NP_001334283.1 cholecystokinin receptor type A isoform 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within axonogenesis IMP
IMP: Inferred from mutant phenotype
15152034 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
15152034 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
15152034 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cckar Protein Structure

CholecysA-Rec_N

CholecysA-Rec_N: pfam09193 (0 - 46)

7tm_GPCRs

7tm_GPCRs: cl28897 (41 - 388)

7tm_GPCRs

7tm_GPCRs: cd14964 (43 - 67)

7tm_GPCRs

7tm_GPCRs: cd14964 (76 - 98)

7tm_GPCRs

7tm_GPCRs: cd14964 (114 - 136)

7tm_GPCRs

7tm_GPCRs: cd14964 (159 - 175)

7tm_GPCRs

7tm_GPCRs: cd14964 (206 - 229)

7tm_GPCRs

7tm_GPCRs: cd14964 (319 - 341)

7tm_GPCRs

7tm_GPCRs: cd14964 (356 - 381)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 436 a.a.
Protein Preferred Names Protein Names

cholecystokinin receptor type A

  • CCK-A receptor

  • CCK-AR

  • CCK1-R

  • cholecystokinin-1 receptor

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-128878 Dexloxiglumide Antagonist 98.25% Phase 3
HY-101764 Lintitript Antagonist 99.58% Phase 2
HY-105257 Pranazepide Antagonist 99.81% Phase 2
HY-11077 SR 146131 Agonist 98.23% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1096 A71623 Agonist 99.34% Unkown
HY-B2154 Loxiglumide Antagonist 98.0% Unkown
HY-129810 PD 135158 Antagonist / Unkown
HY-U00363 CHEMBL333994 Antagonist / Unkown
HY-123434 PD-149164 Agonist / Unkown
HY-119127 TP-680 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cckar NCBI NCBI:886