Cckar - cholecystokinin A receptor Gene

Mus musculus

Gene ID: 12425 | Gene type: protein coding

About Cckar

Chromosome 5: 53,855,118-53,865,047 reverse strand.GRCm39:CM000998.3

This gene has 3 transcripts (splice variants), 202 orthologues, 16 paralogues and is associated with 21 phenotypes. Biased expression in lung adult (RPKM 14.7), kidney adult (RPKM 12.1) and 4 other tissues.

Summary

Predicted to enable Cholecystokinin Receptor activity and peptide hormone binding activity. Acts upstream of or within axonogenesis; forebrain development; and neuron migration. Predicted to be located in several cellular components, including endosome; lysosome; and terminal bouton. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CCKAR (cholecystokinin A receptor). [provided by Alliance of Genome Resources, Apr 2022]

Cckar Products(2)

mRNA	Protein	Name
NM_009827.2	NP_033957.1	cholecystokinin receptor type A isoform 1
NM_001347354.1	NP_001334283.1	cholecystokinin receptor type A isoform 2

Cckar Protein Structure

CholecysA-Rec_N

7tm_GPCRs

0
100
200
300
400
436 a.a.

Protein Preferred Names

Protein Names

cholecystokinin receptor type A

CCK-A receptor	CCK-AR
CCK1-R	cholecystokinin-1 receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1096	A71623	Agonist	99.90%	Unkown
HY-B2154	Loxiglumide	Antagonist	≥98.0%	Unkown
HY-129810	PD 135158	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cckar	NCBI	NCBI:886

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