Cdkn2b - cyclin dependent kinase inhibitor 2B Gene

Also Known as p15; MTS2; INK4b; p15INK4b; p15(INK4b)

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12579

Summary

Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity and protein kinase binding activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle and spleen development. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; immune system; lung; and retina. Human ortholog(s) of this gene implicated in carcinoma (multiple); erythema infectiosum; hematologic Cancer (multiple); open-angle glaucoma; and urinary bladder Cancer. Orthologous to human CDKN2B (cyclin dependent kinase inhibitor 2B). [provided by Alliance of Genome Resources, Apr 2022]

Cdkn2b Products (1)

mRNA Protein Name
NM_007670.4 NP_031696.1 cyclin-dependent kinase 4 inhibitor B

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
23154982 MGI
acts upstream of or within spleen development IGI
IGI: Inferred from genetic interaction
22560297 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclin-dependent kinase 4 inhibitor B

  • cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

  • cyclin-dependent kinase inhibitor p15

  • cyclin-dependent kinase inhibitor p15INK4b

  • cyclin-dependent kinase inhibitor protein

  • p14-INK4b

  • p15-INK4b

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02416 CDKN2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21103 Cdkn2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27622 Cdkn2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdkn2b NCBI NCBI:1030