Cfc1 - cripto, FRL-1, cryptic family 1 Gene

Also Known as cryptic; b2b970Clo

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12627

Summary

Enables activin receptor binding activity. Involved in nodal signaling pathway. Acts upstream of or within several processes, including animal organ development; digestive tract morphogenesis; and endoderm development. Predicted to be located in plasma membrane. Predicted to be active in cell surface and extracellular region. Is expressed in several structures, including embryo mesoderm; intermediate mesenchyme; neural ectoderm; and primitive streak. Used to study dextro-looped transposition of the great arteries; double outlet right ventricle; right atrial isomerism; and visceral heterotaxy. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human CFC1 (cripto, FRL-1, cryptic family 1) and CFC1B (cripto, FRL-1, cryptic family 1B). [provided by Alliance of Genome Resources, Apr 2022]

Cfc1 Products (1)

mRNA Protein Name
NM_007685.2 NP_031711.1 cryptic protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables activin receptor binding IPI
IPI: Inferred from physical interaction
12052855 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anatomical structure development IGI
IGI: Inferred from genetic interaction
11412024 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
11412024 MGI
acts upstream of or within atrial septum morphogenesis IMP
IMP: Inferred from mutant phenotype
10521397 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
10521397 MGI
acts upstream of or within digestive tract morphogenesis IMP
IMP: Inferred from mutant phenotype
10521397 MGI
acts upstream of or within endoderm development IGI
IGI: Inferred from genetic interaction
11412024 MGI
acts upstream of or within heart looping IMP
IMP: Inferred from mutant phenotype
10521397 MGI
acts upstream of or within heart morphogenesis IMP
IMP: Inferred from mutant phenotype
10521397 MGI
acts upstream of or within left lung morphogenesis IMP
IMP: Inferred from mutant phenotype
10521397 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
10521397 MGI
involved in nodal signaling pathway IMP
IMP: Inferred from mutant phenotype
12052855 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
10521397 MGI
acts upstream of or within respiratory system development IMP
IMP: Inferred from mutant phenotype
10521397 MGI
acts upstream of or within spleen development IMP
IMP: Inferred from mutant phenotype
10521397 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cryptic protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02558 CFC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21309 Cfc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27828 Cfc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cfc1 NCBI NCBI:55997