Ccr3 - chemokine (C-C motif) receptor 3 Gene

Also Known as CKR3; Cmkbr3; CC-CKR3; Cmkbr1l2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12771

About Ccr3

Chromosome 9: 123,822,009-123,831,726 forward strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 142 orthologues, 25 paralogues and is associated with 22 phenotypes. Biased expression in spleen adult (RPKM 2.4), subcutaneous fat pad adult (RPKM .5) and 4 other tissues.

Summary

Enables C-C chemokine binding activity and C-C Chemokine Receptor activity. Involved in positive regulation of angiogenesis and positive regulation of endothelial cell proliferation. Acts upstream of or within chemotaxis. Predicted to be located in endosome; extracellular space; and plasma membrane. Predicted to be active in cytoplasm and external side of plasma membrane. Is expressed in embryo and yolk sac. Human ortholog(s) of this gene implicated in asthma; ovary epithelial cancer; and rhinitis. Orthologous to human CCR3 (C-C motif Chemokine Receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Ccr3 Products (1)

mRNA Protein Name
NM_009914.4 NP_034044.3 probable C-C chemokine receptor type 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables C-C chemokine binding IPI
IPI: Inferred from physical interaction
12538707 MGI
enables C-C chemokine receptor activity IDA
IDA: Inferred from direct assay
7594543 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7594543 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chemotaxis IDA
IDA: Inferred from direct assay
7594543 MGI
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
19525930 MGI
involved in positive regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
19525930 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ccr3 Protein Structure

7tmA_CCR3

7tmA_CCR3: cd15185 (38 - 65)

7tmA_CCR3

7tmA_CCR3: cd15185 (38 - 315)

7tmA_CCR3

7tmA_CCR3: cd15185 (72 - 97)

7tmA_CCR3

7tmA_CCR3: cd15185 (109 - 139)

7tmA_CCR3

7tmA_CCR3: cd15185 (151 - 173)

7tmA_CCR3

7tmA_CCR3: cd15185 (199 - 228)

7tmA_CCR3

7tmA_CCR3: cd15185 (235 - 265)

7tmA_CCR3

7tmA_CCR3: cd15185 (283 - 308)

  • 0
  • 100
  • 200
  • 300
  • 359 a.a.
Protein Preferred Names Protein Names

probable C-C chemokine receptor type 3

  • C-C CKR-3

  • CC chemokine receptor 3

  • CC-CKR-3

  • CCR-3

  • MIP-1 alpha RL2

  • MIP-1 alphaRL2

  • chemokine (C-C) receptor 1,-like 2

  • chemokine (C-C) receptor 3

  • macrophage inflammatory protein 1-alpha receptor-like 2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-136788 ALK4290 Inhibitor 99.79% Phase 2

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-103363 SB-328437 Antagonist 99.58% Unkown
HY-103360 J-113863 Antagonist ≥99.0% Unkown
HY-107051 GW 766994 Antagonist 98.73% Unkown
HY-103361 SB297006 Antagonist 99.86% Unkown
HY-P3982 CKLF1-C19 Chemical 99.11% Unkown
HY-U00331 CCR3 antagonist 1 Antagonist 99.90% Unkown
HY-182736 YM-344484 Antagonist / Unkown
HY-N10397 Maceneolignan H Antagonist / Unkown
HY-160998 YM-344031 Antagonist / Unkown
HY-182735 BMS-570520 Antagonist / Unkown
HY-182439 AZD3778 Inhibitor / Unkown
HY-120629 BMS-639623 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ccr3 NCBI NCBI:1232