Col1a1 - collagen, type I, alpha 1 Gene

Also Known as Cola1; Mov13; Cola-1; Mov-13; Col1a-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12842

Summary

This gene encodes the alpha-1 subunit of the fibril-forming type I Collagen, the most abundant protein of bone, skin and tendon extracellular matrices. The encoded protein, in association with alpha-2 subunit, forms heterotrimeric type I procollagen that undergoes proteolytic processing during fibril formation. Mice lacking the encoded protein die in utero caused by the rupture of a major blood vessel. Transgenic mice expressing significantly lower levels of this gene exhibit morphological and functional defects in mineralized and non-mineralized connective tissue and, progressive loss of hearing. [provided by RefSeq, Nov 2015]

Col1a1 Products (1)

mRNA Protein Name
NM_007742.4 NP_031768.2 collagen alpha-1(I) chain preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables extracellular matrix structural constituent IDA
IDA: Inferred from direct assay
15383546 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
9213002 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7629088 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
14630726 MGI
acts upstream of or within bone trabecula formation IGI
IGI: Inferred from genetic interaction
17440987 MGI
acts upstream of or within cartilage development involved in endochondral bone morphogenesis IMP
IMP: Inferred from mutant phenotype
18248096 MGI
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
20548288 MGI
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
21625049 MGI
acts upstream of or within endochondral ossification IMP
IMP: Inferred from mutant phenotype
8130375 MGI
acts upstream of or within face morphogenesis IGI
IGI: Inferred from genetic interaction
17440987 MGI
acts upstream of or within intramembranous ossification IGI
IGI: Inferred from genetic interaction
17440987 MGI
acts upstream of or within negative regulation of cell-substrate adhesion IDA
IDA: Inferred from direct assay
17018525 MGI
involved in osteoblast differentiation IEP
IEP: Inferred from expression pattern
16311053 MGI
acts upstream of or within protein transport IMP
IMP: Inferred from mutant phenotype
8906420 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
8163675 MGI
acts upstream of or within skeletal system morphogenesis IGI
IGI: Inferred from genetic interaction
17440987 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
18248096 MGI
Cellular Component GO Annotation Evidence References Source
part of collagen trimer IDA
IDA: Inferred from direct assay
7704020 MGI
part of collagen trimer IMP
IMP: Inferred from mutant phenotype
14630726 MGI
part of collagen type I trimer IDA
IDA: Inferred from direct assay
8018053 MGI
part of collagen type I trimer IMP
IMP: Inferred from mutant phenotype
7790374 MGI
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
34368841 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
8018053 MGI
located in extracellular matrix IDA
IDA: Inferred from direct assay
2209468 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
34368841 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

collagen alpha-1(I) chain

  • alpha-1 type 1 collagen

  • alpha-1 type I collagen

  • procollagen, type I, alpha 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99047 Simtuzumab Inhibitor ≥99.0% Phase 2

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-151932 FXR agonist 3 Agonist 96.51% Unkown
HY-158231 Polyether F127 Diacrylate Activator / Unkown
HY-47888 PLN-1474 Inhibitor 99.35% Unkown
HY-Y1123 2-Aminoacetamide hydrochloride Activator 99.89% Unkown
HY-146434 TGFβ-IN-2 Inhibitor 99.37% Unkown
HY-120006A (rel)-AR234960 Agonist 98.95% Unkown
HY-W019901B Anhydrous calcium sulfate (97%) Activator 99.40% Unkown
HY-P11223 CMF9 Inhibitor 98.65% Unkown
HY-P5237 Tetrapeptide-4 Activator 99.54% Unkown
HY-147195 QH536 Inhibitor / Unkown
HY-154979 Anti-hepatic fibrosis agent 2 / Unkown
HY-155328 GK444 Inhibitor / Unkown
HY-172258 5-HT2B antagonist-2 Inhibitor / Unkown
HY-175496 Acid Ceramidase-IN-3 Inhibitor / Unkown
HY-176737 TGF-β1/Smad-IN-1 Inhibitor / Unkown
HY-178477 LIFR/GPBAR1 modulator 1 / Unkown
HY-179042 TGF-β/Smad-IN-3 Inhibitor / Unkown
HY-181655 Cathepsin D degrader 1 Degrader / Unkown
HY-181993 JNK3-IN-11 Inhibitor / Unkown
HY-184149 ROCK2-IN-17 Inhibitor / Unkown
HY-RS02970 COL1A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16961 Col1a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23404 Col1a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992066 Anti-Mouse DDR2 Antibody (DAB0065) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Col1a1 NCBI NCBI:1277