Crem - cAMP responsive element modulator Gene

Also Known as ICER; ICERI

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12916

Summary

This gene encodes a basic-leucine zipper domain-containing protein that localizes to gene promoters, where it binds to the cyclic AMP response element (CRE). Different protein isoforms encoded by this gene may function as either activators or repressors of transcription. Activity of this gene is important in multiple developmental processes, including spermatogenesis. Mutation of this gene causes male infertility. Alternative splicing and promoter usage result in multiple transcript variants for this gene. [provided by RefSeq, Oct 2012]

Crem Products (18)

mRNA Protein Name
NM_001110850.2 NP_001104320.1 cAMP-responsive element modulator isoform 4
NM_001110851.1 NP_001104321.1 cAMP-responsive element modulator isoform 7
NM_001110852.1 NP_001104322.1 cAMP-responsive element modulator isoform 8
NM_001110853.2 NP_001104323.1 cAMP-responsive element modulator isoform 9
NM_001110854.1 NP_001104324.2 cAMP-responsive element modulator isoform 10
NM_001110855.1 NP_001104325.2 cAMP-responsive element modulator isoform 11
NM_001110856.2 NP_001104326.1 cAMP-responsive element modulator isoform 2
NM_001110857.2 NP_001104327.1 cAMP-responsive element modulator isoform 5
NM_001110858.2 NP_001104328.1 cAMP-responsive element modulator isoform 6
NM_001110859.2 NP_001104329.1 cAMP-responsive element modulator isoform 1
NM_001271503.1 NP_001258432.1 cAMP-responsive element modulator isoform 12
NM_001271504.1 NP_001258433.1 cAMP-responsive element modulator isoform 13
NM_001271505.1 NP_001258434.1 cAMP-responsive element modulator isoform 14
NM_001271506.1 NP_001258435.1 cAMP-responsive element modulator isoform 15
NM_001311066.1 NP_001297995.1 cAMP-responsive element modulator isoform 16
NM_001311067.1 NP_001297996.1 cAMP-responsive element modulator isoform 17
NM_001374833.1 NP_001361762.1 cAMP-responsive element modulator isoform 18
NM_013498.3 NP_038526.2 cAMP-responsive element modulator isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
11354513 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23443664 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17056544 MGI
Biological Process GO Annotation Evidence References Source
involved in circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23443664 MGI
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
23443664 MGI
acts upstream of or within glycosphingolipid metabolic process IMP
IMP: Inferred from mutant phenotype
18308723 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
23443664 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
20488182 MGI
involved in response to cAMP IDA
IDA: Inferred from direct assay
23443664 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
14757819 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23443664 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
11354513 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cAMP-responsive element modulator

  • cAMP responsive element moderator

  • inducible cAMP early repressor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03165 CREM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20710 Crem Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27221 Crem Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Crem NCBI NCBI:1390