2. Gene
  3. Ctsl - cathepsin L Gene

Ctsl - cathepsin L Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as fs; MEP; nkt; CatL; Ctsl1; 1190035F06Rik

Gene ID: 13039 | Gene type: protein coding

About Ctsl

Chromosome 13: 64,507,151-64,518,704 reverse strand.GRCm39:CM001006.3

This gene has 7 transcripts (splice variants), 241 orthologues, 24 paralogues and is associated with 115 phenotypes. Broad expression in placenta adult (RPKM 194.5), liver E18 (RPKM 75.5) and 2 other tissues.

Summary

This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the activation peptide and the Cathepsin L1 heavy and LIGHT chains. The mature Enzyme appears to be important in embryonic development through its processing of histone H3 and may play a role in disease progression in a model of kidney disease. Homozygous knockout mice for this gene exhibit hair loss, skin thickening, bone and heart defects, and enhanced susceptibility to Bacterial infection. A pseudogene of this gene has been identified in the genome. [provided by RefSeq, Aug 2015]

Ctsl Products(1)

mRNA Protein Name
NM_009984.4 NP_034114.1 procathepsin L preproprotein

Ctsl Protein Structure

Inhibitor_I29

Inhibitor_I29: smart00848 (28 - 86)

Peptidase_C1

Peptidase_C1: pfam00112 (113 - 331)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

procathepsin L

cathepsin L1

Cat L

major excreted protein

p39 cysteine proteinase

Recombinant Ctsl Proteins

Cat. No. Product Name Accession Purity
HY-P7753 Cathepsin L1 Protein, Mouse (HEK293, His) P06797 (T18-N334) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-137978A Ezurpimtrostat hydrochloride Inhibitor 98.29% Phase 2
HY-137978 Ezurpimtrostat Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-128140 Z-FY-CHO Inhibitor 96.18% Unkown
HY-119293 K777 99.77% Unkown
HY-157477 SARS-CoV-2 3CLpro-IN-22 Inhibitor / Unkown
HY-158022 CTSL/CAPN1-IN-1 Inhibitor / Unkown
HY-161342 CTSL/CAPN1-IN-2 Inhibitor / Unkown
HY-RS03340 CTSL Human Pre-designed siRNA Set A / Unkown
HY-RS03341 Ctsl Mouse Pre-designed siRNA Set A / Unkown
HY-RS03342 Ctsl Rat Pre-designed siRNA Set A / Unkown
HY-163029 CTSL/B-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctsl NCBI NCBI:1514