Ctsl - cathepsin L Gene

Also Known as fs; MEP; nkt; CatL; Ctsl1; 1190035F06Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13039

About Ctsl

Chromosome 13: 64,507,151-64,518,704 reverse strand.GRCm39:CM001006.3

This gene has 7 transcripts (splice variants), 241 orthologues, 24 paralogues and is associated with 115 phenotypes. Broad expression in placenta adult (RPKM 194.5), liver E18 (RPKM 75.5) and 2 other tissues.

Summary

This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the activation peptide and the Cathepsin L1 heavy and light chains. The mature enzyme appears to be important in embryonic development through its processing of histone H3 and may play a role in disease progression in a model of kidney disease. Homozygous knockout mice for this gene exhibit hair loss, skin thickening, bone and heart defects, and enhanced susceptibility to Bacterial infection. A pseudogene of this gene has been identified in the genome. [provided by RefSeq, Aug 2015]

Ctsl Products (1)

mRNA	Protein	Name
NM_009984.4	NP_034114.1	procathepsin L preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type carboxypeptidase activity	IDA IDA: Inferred from direct assay	11023992	MGI
enables endopeptidase activity	IMP IMP: Inferred from mutant phenotype	18450756	MGI
enables histone binding	IDA IDA: Inferred from direct assay	18957203	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11483509	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in CD4-positive, alpha-beta T cell lineage commitment	IMP IMP: Inferred from mutant phenotype	9545226	MGI
involved in antigen processing and presentation of peptide antigen	IMP IMP: Inferred from mutant phenotype	9545226	MGI
acts upstream of or within catagen	IMP IMP: Inferred from mutant phenotype	11023992	MGI
involved in collagen catabolic process	IDA IDA: Inferred from direct assay	10716919	MGI
acts upstream of or within decidualization	IGI IGI: Inferred from genetic interaction	9310336	MGI
involved in elastin catabolic process	IMP IMP: Inferred from mutant phenotype	12417635	MGI
NOT involved in epithelial tube branching involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	17500053	MGI
acts upstream of or within hair follicle morphogenesis	IMP IMP: Inferred from mutant phenotype	11023992	MGI
acts upstream of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	11023992	MGI
acts upstream of or within negative regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	11023992	MGI
involved in proteolysis	IDA IDA: Inferred from direct assay	18957203	MGI
involved in proteolysis involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	12782676	MGI
involved in thyroid hormone generation	IMP IMP: Inferred from mutant phenotype	12782676	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	9310336	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	12782676	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	9310336	MGI
located in lysosome	IDA IDA: Inferred from direct assay	11023992	MGI
located in nucleolus	IDA IDA: Inferred from direct assay	20338168	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18957203	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ctsl Protein Structure

Inhibitor_I29

Peptidase_C1

0
100
200
300
334 a.a.

Protein Preferred Names	Protein Names
procathepsin L cathepsin L1	Cat L major excreted protein p39 cysteine proteinase

Protein Preferred Names

Protein Names

procathepsin L

cathepsin L1

Cat L
major excreted protein
p39 cysteine proteinase

Recombinant Ctsl Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7753	Cathepsin L1 Protein, Mouse (HEK293, His)	P06797 (T18-N334)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-128140	Z-FY-CHO	Inhibitor	96.18%	Unkown
HY-119293	K777	Inhibitor	99.14%	Unkown
HY-170772	Dual Cathepsin L/JAK-IN-1	Inhibitor	98.47%	Unkown
HY-RS03340	CTSL Human Pre-designed siRNA Set A		/	Unkown
HY-119293A	K777 tosylate	Inhibitor	/	Unkown
HY-157477	SARS-CoV-2 3CLpro-IN-22	Inhibitor	/	Unkown
HY-158022	CTSL/CAPN1-IN-1	Inhibitor	/	Unkown
HY-161342	CTSL/CAPN1-IN-2	Inhibitor	/	Unkown
HY-181676	Anti-inflammatory agent 113	Inhibitor	/	Unkown
HY-RS03341	Ctsl Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS03342	Ctsl Rat Pre-designed siRNA Set A		/	Unkown
HY-163029	CTSL/B-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ctsl	NCBI	NCBI:1514