Dnmt3b - DNA methyltransferase 3B Gene

Also Known as MmuIIIB

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13436

Summary

This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene results in severe developmental defects and loss of viability. Mutation of the related gene in humans causes immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. There is a pseudogene for this gene located adjacent to this gene in the same region of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012]

Dnmt3b Products (9)

mRNA	Protein	Name
NM_001003960.4	NP_001003960.2	DNA (cytosine-5)-methyltransferase 3B isoform 2
NM_001003961.4	NP_001003961.2	DNA (cytosine-5)-methyltransferase 3B isoform 1
NM_001003963.4	NP_001003963.2	DNA (cytosine-5)-methyltransferase 3B isoform 4
NM_001122997.2	NP_001116469.1	DNA (cytosine-5)-methyltransferase 3B isoform 5
NM_001271744.1	NP_001258673.1	DNA (cytosine-5)-methyltransferase 3B isoform 1
NM_001271745.1	NP_001258674.1	DNA (cytosine-5)-methyltransferase 3B isoform 2
NM_001271746.1	NP_001258675.1	DNA (cytosine-5)-methyltransferase 3B isoform 4
NM_001271747.1	NP_001258676.1	DNA (cytosine-5)-methyltransferase 3B isoform 3
NM_010068.5	NP_034198.3	DNA (cytosine-5)-methyltransferase 3B isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA (cytosine-5-)-methyltransferase activity	IDA IDA: Inferred from direct assay	9662389	MGI
enables DNA (cytosine-5-)-methyltransferase activity	IGI IGI: Inferred from genetic interaction	17938196	MGI
enables DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates	IDA IDA: Inferred from direct assay	27856912	MGI
enables DNA binding	IDA IDA: Inferred from direct assay	21378119	MGI
enables lncRNA binding	IDA IDA: Inferred from direct assay	25686699	MGI
enables methyltransferase activity	IDA IDA: Inferred from direct assay	11919202	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11934864	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within DNA methylation-dependent heterochromatin formation	IGI IGI: Inferred from genetic interaction	17938196	MGI
acts upstream of or within autosome genomic imprinting	IMP IMP: Inferred from mutant phenotype	11934864	MGI
acts upstream of or within cellular response to amino acid stimulus	IDA IDA: Inferred from direct assay	20548288	MGI
acts upstream of or within epigenetic programming of gene expression	IGI IGI: Inferred from genetic interaction	10555141	MGI
involved in epigenetic regulation of gene expression	IEP IEP: Inferred from expression pattern	18814855	MGI
acts upstream of or within gene silencing by piRNA-directed DNA methylation	IDA IDA: Inferred from direct assay	27856912	MGI
acts upstream of or within heterochromatin formation	IMP IMP: Inferred from mutant phenotype	22516971	MGI
involved in negative regulation of gene expression, epigenetic	IMP IMP: Inferred from mutant phenotype	18056424	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22133874	MGI
acts upstream of or within protein-containing complex localization	IDA IDA: Inferred from direct assay	16543361	MGI
acts upstream of or within retrotransposon silencing by heterochromatin formation	IDA IDA: Inferred from direct assay	27856912	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromosome, centromeric region	IDA IDA: Inferred from direct assay	15456878	MGI
located in heterochromatin	IDA IDA: Inferred from direct assay	11934864	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16543361	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
DNA (cytosine-5)-methyltransferase 3B	DNA MTase MmuIIIB DNA methyltransferase MmuIIIB

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-W286743	Nε-(Carboxymethyl)-L-lysine	Activator	99.70%	Phase 3

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135146	GSK-3484862		99.95%	Unkown
HY-13962	SGI-1027		99.79%	Unkown
HY-101925	CM-272		99.55%	Unkown
HY-103397	Nanaomycin A	Inhibitor	98.18%	Unkown
HY-124131	DS-437	Inhibitor	99.22%	Unkown
HY-111544	EML741	Inhibitor	/	Unkown
HY-181955	MS1129		/	Unkown
HY-135146G	GSK-3484862 (GMP)		/	Unkown
HY-13689G	Go 6983 (GMP)		/	Unkown
HY-149389	PNMT-IN-1	Inhibitor	/	Unkown
HY-182009	DNMT-IN-6		/	Unkown
HY-182956	DNMT1 Degrader-1	Degrader	/	Unkown
HY-RS03912	DNMT3B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-103397R	Nanaomycin A (Standard)	Inhibitor	/	Unkown
HY-RS16772	Dnmt3b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23212	Dnmt3b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dnmt3b	NCBI	NCBI:1789