Drd3 - dopamine receptor D3 Gene

Mus musculus

Also known as D3R

Gene ID: 13490 | Gene type: protein coding

About Drd3

Chromosome 16: 43,574,389-43,643,295 forward strand.GRCm39:CM001009.3

This gene has 2 transcripts (splice variants), 206 orthologues, 32 paralogues and is associated with 39 phenotypes. Low expression observed in reference dataset.

Summary

Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in behavioral response to cocaine and regulation of neurotransmitter uptake. Acts upstream of or within several processes, including regulation of blood pressure; regulation of Dopamine Receptor signaling pathway; and response to alkaloid. Located in plasma membrane. Is active in dopaminergic synapse. Is expressed in several structures, including brain; exocrine gland; genitourinary system; gut; and sensory organ. Used to study restless legs syndrome. Human ortholog(s) of this gene implicated in Parkinson's disease; essential tremor; essential tremor 1; and schizophrenia. Orthologous to human DRD3 (Dopamine Receptor D3). [provided by Alliance of Genome Resources, Apr 2022]

Drd3 Products(1)

mRNA	Protein	Name
NM_007877.2	NP_031903.1	D(3) dopamine receptor

Drd3 Protein Structure

7tmA_D3_dopamine_R

0
100
200
300
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446 a.a.

Protein Preferred Names

Protein Names

D(3) dopamine receptor

dopamine D3 receptor

dopamine receptor 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19654	GSK598809	Antagonist	99.73%	Unkown
HY-19654C	(-)-GSK598809 hydrochloride	Antagonist	99.64%	Unkown
HY-19654B	(-)-GSK598809	Antagonist	/	Unkown
HY-RS04000	DRD3 Human Pre-designed siRNA Set A		/	Unkown
HY-RS04001	Drd3 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS04002	Drd3 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Drd3	NCBI	NCBI:1814

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