Dsc3 - desmocollin 3 Gene

Also Known as 5430426I24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13507

Summary

This gene encodes a member of the Cadherin family of proteins that mediates adhesion in desmosomes. Together with desmogleins, the encoded protein forms the transmembrane core of desmosomes, a multiprotein complex involved in cell adhesion, organization of the Cytoskeleton, cell sorting and cell signaling. Mice lacking the encoded protein exhibit a pre-implantation lethal phenotype. This gene is located in a cluster of desmosomal Cadherin genes on chromosome 18. This gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein. [provided by RefSeq, Jul 2016]

Dsc3 Products (2)

mRNA Protein Name
NM_001291809.1 NP_001278738.1 desmocollin-3 isoform 2 precursor
NM_007882.3 NP_031908.3 desmocollin-3 isoform 1 preproprotein

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
16418220 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16418220 MGI
located in desmosome IDA
IDA: Inferred from direct assay
14673151 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
17015624 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16418220 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

desmocollin-3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04015 DSC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04016 DSC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18352 Dsc3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24831 Dsc3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dsc3 NCBI NCBI:1825
Rattus norvegicus Dsc3 NCBI NCBI:307563